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Mastiff puppies and dogs in Saint Louis, Missouri

Looking for a Mastiff puppy or dog in Saint Louis, Missouri? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Saint Louis, Missouri

These Mastiffs are available in Saint Louis, Missouri.
We'll also keep you updated on Chili Mac's adoption status with email updates.
Photo of Chili Mac

Chili Mac

Mastiff

Male, Puppy
St Louis, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Chili Mac!    This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next.   He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands.   Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed.   Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die!    If interested, please  complete the  Adoption Application  on our website at  www.NeedyPaws.org  and we will contact you.  Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 22, 2025, 7:04 pm

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We'll also keep you updated on Bellatrix's adoption status with email updates.
Photo of Bellatrix

Bellatrix

Mastiff

Female, 8 yrs 1 mo
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Meet Bellatrix – The Gentle Giant with a Harry Potter Twist! Bellatrix may share a name with a famous witch, but don’t worry—she’s all love and loyalty, no dark magic here! This 8-year-old Mastiff is a wise and gentle soul who prefers cuddles over curses and cozy naps over chaos. She absolutely adores people and will happily be your most devoted companion. Bellatrix is potty and crate trained, though she hardly needs her crate it because she’s such a well-mannered lady. Her ideal home? A calm, loving environment where she can relax and feel like the queen of her own Great Hall. She would do best as the only dog in the home. Bellatrix enjoys short strolls, comfy spots like the couch, and being near her favorite humans—she’s basically your very own magical protector. If you’re ready to add a little enchantment (and a lot of love) to your life, Bellatrix is waiting to cast her spell on your heart. Her adoption fee is fully sponsored. Ready to meet Bellatrix? She’s more Hufflepuff than Slytherin—bring her home today! Visit Istodaymydayrescue.org to learn more or fill out an application.

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We'll also keep you updated on Sage's adoption status with email updates.
Photo of Sage

Sage

Mastiff

Female, Adult
Saint Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hi! Sage is what I believe is an iltalian mastiff mix of some sort. Her exact breed is unknown. Her birthday is 2/24/23. She has never resided in a shelter. She was fostered for 2 months through the Stray Reacue, then adopted by me. I am looking to rehome her solely because she is a very social dog who thrives in a home with multiple humans/dogs. Given my sudden life change, I am no longer able to provide that for her. I have noticed her a bit less happy in a home with just myself and her. Please reach out with any additional questions/concerns!

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We'll also keep you updated on Gus's adoption status with email updates.
Photo of Gus

Gus

Mastiff Mixed Breed (Large)

Male, Adult
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

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We'll also keep you updated on Mr. Bojangles's adoption status with email updates.
Photo of Mr. Bojangles

Mr. Bojangles

Mastiff Mixed Breed (Large)

Male, 3 yrs 5 mos
St. Louis, MO
Size
(when grown) -
Details
Spayed or Neutered,
Story
Meet Mr. Bojangles, a distinguished male dog around three years old, who brings both class and a dash of drama to the table! He would like to clarify that the vocalizations you hear from his kennel are not barking, but rather his intensive opera training in progress! Once he's out, this fancy-pants gentleman is incredibly chill and sweet, and he walks like a pro—no pulling, unless nature is making an urgent call. Mr. Bojangles is a certified foodie who appreciates a good gourmet treat but is just as happy with a classic peanut-butter bone. Basically, he’s a loyal companion who is effortlessly refined and ready to serenade his way into your heart!

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We'll also keep you updated on Meryl Streep's adoption status with email updates.
Photo of Meryl Streep

Meryl Streep

Mastiff Mixed Breed (Medium)

Female, 1 yr 10 mos
St. Louis, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
🩷I learned much about adorable Meryl Streep yesterday as we buddied up and attended CARE’S Adoption Event at “Tower Grove Pride” event. This adorable one and a half year-old pup showed her happy self from the moment she jumped in the car and was the perfect backseat rider. 🩷As we walked to CARE’S tent Meryl walked well on the leash. The event was well attended and this sweet pup was friendly and sweet throughout. As participants of all ages came up to say “Hi” and gave her pets she was gentle to everyone. As other dogs passed she was mostly indifferent being content and enjoying the moment. When this precious girl was tired she laid down and fell fast asleep and stayed like that as the action continued all around her. After her short nap we headed back to the car. This precious, perfect girl made the day’s event fun, happy and totally enjoyable for me her sidekick💕 🩷All I could think is this fabulous pup belongs in a loving home and hopefully soon! Meryl Streep, is a treasure and would be a cherished pup for many families. -Her eye condition is called Cherry Eye and is not serious and will be taken care of by CARES clinic when she’s adopted. 🩷She is at CARE STL for you to meet and possibly fall in love just like me🩷🐾XOXO

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Or, how about these Mastiffs in cities near Saint Louis, Missouri

These Mastiffs are available for adoption close to Saint Louis, Missouri.
We'll also keep you updated on Chili Mac's adoption status with email updates.
Photo of Chili Mac

Chili Mac

Mastiff

Male, Puppy
St Louis, MO
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Chili Mac!    This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next.   He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands.   Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed.   Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die!    If interested, please  complete the  Adoption Application  on our website at  www.NeedyPaws.org  and we will contact you.  Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 22, 2025, 7:04 pm

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We'll also keep you updated on Bellatrix's adoption status with email updates.
Photo of Bellatrix

Bellatrix

Mastiff

Female, 8 yrs 1 mo
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Meet Bellatrix – The Gentle Giant with a Harry Potter Twist! Bellatrix may share a name with a famous witch, but don’t worry—she’s all love and loyalty, no dark magic here! This 8-year-old Mastiff is a wise and gentle soul who prefers cuddles over curses and cozy naps over chaos. She absolutely adores people and will happily be your most devoted companion. Bellatrix is potty and crate trained, though she hardly needs her crate it because she’s such a well-mannered lady. Her ideal home? A calm, loving environment where she can relax and feel like the queen of her own Great Hall. She would do best as the only dog in the home. Bellatrix enjoys short strolls, comfy spots like the couch, and being near her favorite humans—she’s basically your very own magical protector. If you’re ready to add a little enchantment (and a lot of love) to your life, Bellatrix is waiting to cast her spell on your heart. Her adoption fee is fully sponsored. Ready to meet Bellatrix? She’s more Hufflepuff than Slytherin—bring her home today! Visit Istodaymydayrescue.org to learn more or fill out an application.

Learn More

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We'll also keep you updated on Sage's adoption status with email updates.
Photo of Sage

Sage

Mastiff

Female, Adult
Saint Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Hi! Sage is what I believe is an iltalian mastiff mix of some sort. Her exact breed is unknown. Her birthday is 2/24/23. She has never resided in a shelter. She was fostered for 2 months through the Stray Reacue, then adopted by me. I am looking to rehome her solely because she is a very social dog who thrives in a home with multiple humans/dogs. Given my sudden life change, I am no longer able to provide that for her. I have noticed her a bit less happy in a home with just myself and her. Please reach out with any additional questions/concerns!

Learn More

Small right facing arrow
We'll also keep you updated on Gus's adoption status with email updates.
Photo of Gus

Gus

Mastiff Mixed Breed (Large)

Male, Adult
St. Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

Learn More

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We'll also keep you updated on Mr. Bojangles's adoption status with email updates.
Photo of Mr. Bojangles

Mr. Bojangles

Mastiff Mixed Breed (Large)

Male, 3 yrs 5 mos
St. Louis, MO
Size
(when grown) -
Details
Spayed or Neutered,
Story
Meet Mr. Bojangles, a distinguished male dog around three years old, who brings both class and a dash of drama to the table! He would like to clarify that the vocalizations you hear from his kennel are not barking, but rather his intensive opera training in progress! Once he's out, this fancy-pants gentleman is incredibly chill and sweet, and he walks like a pro—no pulling, unless nature is making an urgent call. Mr. Bojangles is a certified foodie who appreciates a good gourmet treat but is just as happy with a classic peanut-butter bone. Basically, he’s a loyal companion who is effortlessly refined and ready to serenade his way into your heart!

Learn More

Small right facing arrow
We'll also keep you updated on Meryl Streep's adoption status with email updates.
Photo of Meryl Streep

Meryl Streep

Mastiff Mixed Breed (Medium)

Female, 1 yr 10 mos
St. Louis, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
🩷I learned much about adorable Meryl Streep yesterday as we buddied up and attended CARE’S Adoption Event at “Tower Grove Pride” event. This adorable one and a half year-old pup showed her happy self from the moment she jumped in the car and was the perfect backseat rider. 🩷As we walked to CARE’S tent Meryl walked well on the leash. The event was well attended and this sweet pup was friendly and sweet throughout. As participants of all ages came up to say “Hi” and gave her pets she was gentle to everyone. As other dogs passed she was mostly indifferent being content and enjoying the moment. When this precious girl was tired she laid down and fell fast asleep and stayed like that as the action continued all around her. After her short nap we headed back to the car. This precious, perfect girl made the day’s event fun, happy and totally enjoyable for me her sidekick💕 🩷All I could think is this fabulous pup belongs in a loving home and hopefully soon! Meryl Streep, is a treasure and would be a cherished pup for many families. -Her eye condition is called Cherry Eye and is not serious and will be taken care of by CARES clinic when she’s adopted. 🩷She is at CARE STL for you to meet and possibly fall in love just like me🩷🐾XOXO

Learn More

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These pups are in Saint Louis, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Louis, Missouri. To see more adoptable Mastiffs in Saint Louis, Missouri, use the search tool below to enter specific criteria!
We'll also keep you updated on Mae's adoption status with email updates.
Photo of Mae

Mae

Bullmastiff

Female, Adult
St Louis, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
BASICS: Bullmastiff / female / 5 years old CHILDREN: Yes CATS: Unknown DOGS: Male dogs over 30lbs, with slow introduction and supervision PERSONALITY: Medium energy level; Very sweet and affectionate; Enjoys taking naps in the sun or on the couch, exploring outdoors in the yard, walking the neighborhood and LOVES hanging out with people. Loves men! TRAINING: Housebroken, leash trained, knows basic obedience and how to use a dog door SPECIAL NEEDS: None VETTING: Fully vaccinated, spayed, microchipped Ready to give Mae the forever home of her dreams? Fill out our Adoption Application, located The Bullpen Way Station & Sanctuary under the 'work with us' tab. We highly recommend that our potential adopters fill out an online application as soon as possible, as it greatly expedites the process of finding the right dog for your situation. Our dogs are available for adoption nationwide but preference is given to adopters willing to do an in-person meeting. Please understand that our dogs are not adopted on a first-come, first-served basis, but rather we strive for a "perfect placement" so we know that they will not be failed again.

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We'll also keep you updated on Gambino's adoption status with email updates.
Photo of Gambino

Gambino

Bullmastiff Bull Terrier

Male, 6 yrs 6 mos
St. Louis, MO
Size
(when grown) -
Details
Good with dogs, House-trained, Spayed or Neutered,
Story
Get ready to meet Gambino, a handsome dog with a heart of gold who is just waiting to become your devoted co-pilot in life! This middle-aged gentleman is proof that second chances are beautiful. Gambino has had a rough start, enduring a life chained up outside and then spending several months in a shelter kennel after his rescue. Thankfully, he has been safe in a foster home for the last few weeks, decompressing and learning what it means to be a cherished pet. Now, all he needs is a patient, loving person who can help his past trauma become a distant memory. Gambino is a truly dedicated lover boy, and his favorite place in the world is right by your side. He’s incredibly clingy because he views his person as the most important thing in the world, making him a naturally protective companion. He has a history of making friends easily with women and is simply looking for a confident, patient handler who can help him feel secure and show him the world is safe. He’s food and praise motivated, knows his basic commands, and he loves all the scratches, especially on his neck! He’s also a big fan of toys and chews—rope toys, squeakers, balls, chew bones, you name it, he likes it! Gambino is the total package when it comes to house manners. He is perfectly potty-trained and a star student in his kennel, heading to his crate easily with just a little help from a tasty frozen Kong. He’s a dream on the leash and responds perfectly to "sit" and "no." He would probably prefer a secure fenced-in yard where he can relax and enjoy his time outdoors, without the restriction of a leash. This guy thrives on routine and clear boundaries. Due to his history as a watchdog, he would likely thrive as the solo pet in the home. He's working hard on being a little more gentle with accepting treats (he still gets a little chomp-happy!) but shows great improvement with every new skill he learns. Gambino's ideal home is one where his person is ready for a shadow and a snuggle machine! He is a sweetheart who is just beginning to learn how wonderful life can be. If you're looking for a devoted, cuddly, and house-trained best friend who will make you feel loved and appreciated every single day, look no further than the charming Gambino!

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Saint Louis, Missouri.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Saint Louis, Missouri

Bullmastiffs in Saint Louis, Missouri Neapolitan Mastiffs in Saint Louis, Missouri Saint Bernards in Saint Louis, Missouri

Mastiff shelters & rescues in Saint Louis, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Saint Louis, Missouri. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

4.7 miles

Needy Paws Rescue

St Louis, MO 63125

Pet Types: dogs

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Rescue

6.4 miles

Is Today My Day Rescue

St. Louis, MO 63139

Pet Types: dogs

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Rescue

8.9 miles

Nala and Friends Dog Rescue - ST. LOUIS transport

St. Louis, MO 63118

Pet Types: dogs

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Shelter

10.6 miles

CARE STL

2700 Walnut Place, St. Louis, MO 63103

Pet Types: cats, birds, dogs, farm animals, rabbits, small animals

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Rescue

10.9 miles

Gods Dogs Rescue of TX for St Louis Transport Stop

St Louis, MO 63146

Pet Types: dogs

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Shelter

10.9 miles

Humane Society of Missouri - Maryland Heights

11660 Administration Dr., (Page Ave. and Schuetz Road), Maryland Heights, MO 63146

Pet Types: cats, birds, dogs, rabbits, small animals

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Shelter

14.2 miles

Gateway Pet Guardians

725 N 15th St, East ST Louis, IL 62205

Pet Types: cats, dogs

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Rescue

16.4 miles

Charming Pet Rescue - MO Transport Stop

St. Louis, MO 63303

Pet Types: dogs

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Shelter

20.7 miles

St Charles County Humane Services

4850 Mid Rivers Mall Dr, St. Peters, MO 63376

Pet Types: cats, birds, dogs, rabbits, small animals

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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