Mastiff Adoption in Webster Groves, MO: Mastiff Puppies for Sale in Webster Groves, MO

Adopt a Mastiff near you in Webster Groves, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Webster Groves, Missouri

These Mastiffs are available for adoption close to Webster Groves, Missouri.

WALTER

Mastiff

Male, 5 yrs

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Walter is friendly, outgoing, and his happiness is contagious. He walks well on a leash and seems to be potty trained. He knows sit, loves to play with squeekie toys, and wants all the pets.

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Bellatrix aka "Willow Eliza"

Mastiff

Female, 8 yrs 1 mo

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Bella is big and beautiful with a personality to match. This six-year-old mastiff mix girl adores people, snuggles, pets, and attention. She is spayed and up-to-date on all her medical care and is heartworm-negative. Bella is a big girl, approximately 65 pounds, so while she is very good with people, she would be best with older kids who can keep up with her size. She is house-trained, and a fenced yard would be best since Bella is a large dog and likes to play. Bella likes her people so much she doesn't want to share and would do best as the only dog in her home. To meet Bella, visit istodaymydayrescue.org to fill out an application. Her adoption fee is $100.

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter.Visit this organization's web site to see any additional information available about this pet.November 12, 2025, 2:35 pm

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Sage

Mastiff

Female, Adult

Saint Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Hi! Sage is what I believe is an iltalian mastiff mix of some sort. Her exact breed is unknown. Her birthday is 2/24/23. She has never resided in a shelter. She was fostered for 2 months through the Stray Reacue, then adopted by me. I am looking to rehome her solely because she is a very social dog who thrives in a home with multiple humans/dogs. Given my sudden life change, I am no longer able to provide that for her. I have noticed her a bit less happy in a home with just myself and her. Please reach out with any additional questions/concerns!

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Gus

Mastiff Mixed Breed (Large)

Male, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Gus! Gus is a charming 3-year-old mastiff mix with a heart as big as his paws. This gentle giant is friendly, outgoing, and absolutely loves people. He gets along wonderfully with other dogs and kids—just be prepared for a little “bull in a china shop” energy when he gets excited! Gus is house-trained, kennel-trained, and making great progress with his leash skills. He’s also an excellent car buddy, happy to settle in and enjoy the ride. If you’re looking for a lovable, goofy companion who brings joy wherever he goes, Gus might just be your perfect match! https://www.shelterluv.com/matchme/adopt/NAF/Dog

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Compton

Mastiff Labrador Retriever

Male, 2 yrs 11 mos

St. Louis, MO

Size

(when grown) -

Details

Good with dogs, Not good with cats, House-trained, Spayed or Neutered,

Story

Compton is a big-hearted, laid-back pup who’s been through a lot and is now searching for the perfect home to call his own. Found abandoned in a park back in January with a collar and lead still attached, it’s clear that he was once someone’s pet—but now he’s looking for a family that truly understands him. Shelter life has been stressful for him, making his search for a loving home even more urgent. While he’s an absolute sweetheart, he thrives best in a calm environment without young kids, as their energy and unpredictability seem to overwhelm him. Otherwise, Compton is truly the bestest boy! This gentle lug is fully crate-trained—though a little hesitant to go in at first, a toy will convince him, and once inside, he settles quietly. He’s also potty trained and will patiently sit by the door to let you know when it’s time to go out. A dream passenger in the car, Compton enjoys gazing out the window or relaxing for the ride. He walks beautifully on a loose leash and has done well with the few dogs he’s met, suggesting he could be a great canine companion with proper introductions. At his core, Compton is just a big teddy bear who deserves all the love in a peaceful, understanding home. If you’re looking for a loyal and affectionate best friend, Compton is ready to be your perfect companion.

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Mastiff puppies and dogs in Webster Groves, Missouri

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Adopt a Mastiff near you in Webster Groves, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Webster Groves, Missouri

These Mastiffs are available for adoption close to Webster Groves, Missouri.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Webster Groves, Missouri

Mastiff shelters & rescues in Webster Groves, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics