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Mastiff puppies and dogs in Ephrata, Pennsylvania

Looking for a Mastiff puppy or dog in Ephrata, Pennsylvania? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Ephrata, Pennsylvania

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Or, how about these Mastiffs in cities near Ephrata, Pennsylvania

These Mastiffs are available for adoption close to Ephrata, Pennsylvania.
Photo of Meatball

Meatball

Mastiff Mixed Breed (Large)

Male, 3 yrs 11 mos
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with cats, Spayed or Neutered,
Story
Meatball came to us as a stray with an injured tail, and our medical team has worked hard to help him heal and feel his best. Now that he’s doing better, this adorable big guy is ready to find a family of his own! Meatball can be a little reserved when meeting new people, but once he’s comfortable, his playful and affectionate side starts to shine. He’s looking for a family who can appreciate both his sweet side and his adventurous spirit. Meatball will need a home without cats or small animals. If you’re ready for a big guy with a big heart, Meatball may be your perfect match! 3159 Susquehanna Trail N York PA 17406 Kennel #3537
Photo of Road Runner

Road Runner

Mastiff

Male, 9 yrs
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Road Runner is a sweet older Mastiff who came to us as a stray. Unfortunately, when he first arrived to us he had some medical issues that needed attention. Road Runner is feeling much better these days though and he’s ready to find his family. Road Runner is estimated to be about 9 years old and does come with some older gentleman needs that any future family should be prepared for. Road Runner has a BIG bark, but behind that big voice is an even bigger love bug. He is happiest when he can be close to his people and would love nothing more than to find a family who will give him the comfort, patience, and companionship he deserves for his golden years. Soft spot for seniors? Come meet Road Runner! 3159 Susquehanna Trail N York PA 17406 Kennel #3537
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Photo of YORK-Stray-16885

YORK-Stray-16885

Mastiff

Male, 3 yrs 9 mos
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
I was found on Cape Horn Rd, York TWP
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Photo of YORK-Stray-16869

YORK-Stray-16869

Mastiff

Female, 3 yrs 9 mos
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
I was found on Arbor Drive, North Hopewell TWP
Photo of Gus Gus

Gus Gus

English Mastiff Cane Corso

Male, Young
Exton, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application HEADLINER : Gus Gus, the Giant, Loveable Goofball  HISTORY : Gus Gus, of no fault of his own, came to MTM from a loving family. Former family reported him being great with other dogs and cats as well as kids.... though he has been reported to find and eat socks  PERSONALITY : Mild-mannered, passive with our male dog, loves laying around and hanging out. Always  down for car rides and is quite a good hiking partner. He is a sucker for treats and belly rubs, though be  aware that we tend to call him Gus Gus "Niagara Falls" after he drinks, as much of the water that goes in tends to dribble back out... nothing a few old towels cannot handle. This dog is a HUGE love-bug!  FAVORITE ACTIVITIES : Greeting his people, walks, playing with sticks, playing with other dogs and kids, car rides with windows down, eating treats and lots of chilling.  MEDICAL ISSUES : Currently waiting for his neuter surgery (scheduled for early November), is on an antibiotic for yeasty ears, and is being treated for infected pressure sores on his legs from laying on hard floors (he has been getting used to dog beds and sometimes the couch during his time with his foster family). He has lost weight (was 225 and is currently 192 lbs.) and is working on gaining it back. Tested positive for Lyme Disease on 9/11/26. Currently up to date with vaccines and is on heart guard treatment  WHAT WOULD BE THE BEST KIND OF HOME: A loving home that can give Gus Gus plenty of car rides and leisure walks and nice hikes in nature. A home with people that love him and his big head, even if he drools. A home that has room for a big couch potato sidekick. He has been great with his foster-brother dog (a male great dane) and our 2 teenage sons.  Click here to watch a video of Gus Gus.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. ​Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   October 4, 2026, 5:43 pm
Photo of Cosmo

Cosmo

Mastiff

Female, Puppy
Exton, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Shots are up-to-date,
Story
You can fill out an adoption application online on our official website. Fill out an Adoption Application Click here to watch a video of Cosmo.Visit this organization's web site to see any additional information available about this pet. Application Fees, Adoption Donations and Rescue Policy: Please know that 100% of our fees and donations pay for the costs of rescuing dogs. These include but are not limited to pull fees from shelters, veterinary examinations, vaccinations, medications and care, microchips, neuter/spay surgeries, heartworm treatments, behavior evaluations, and foster care, as needed. Important notes before applying. Approved adopters must have their primary residence in one of the following states: Delaware, Maryland, Michigan, New Jersey, Ohio, Pennsylvania, West Virginia, Virginia, and parts of North Carolina and Kentucky. You must be at least 21 years of age to apply and legally sign our contract for adoption. Applications must be completed by the homeowner.  We do not adopt giant breed dogs to renters. If you are renting, and you are applying to adopt a dog that is not a giant breed, permission to adopt an animal must be obtained from the landlord or property owner. We do not adopt giant breed dogs to homes with children under 6 years of age. Homes with children should have a fenced yard. Applications will be denied if anyone residing in the household has a record indicating drug/alcohol abuse, theft, or violence. Pets currently in the applicant's home must have a history of appropriate veterinary care. Homes with intact dogs will not be approved for adoption.  Proof of any of the following exceptions is required: The intact dog is a working member of a law enforcement, or search and rescue/recovery team. The intact dog is registered under the auspices of the American Kennel Club and is actively being shown. A veterinarian has determined the sterilization procedure would harm the intact dog.  We believe in Force Free Training Methods and do not approve of methods or devices using pain or force to control the dog, or to deter undesirable behavior.  Homes with highly varnished steps must have carpeting, securely fixed stair treads, or a non-skid surface. **We encourage you to remediate potential safety issues while your application is under review, prior to the home visit. ​Any inside steps to which the dog(s) have access, must have carpeting, securely fixed stair treads, or a non-skid surface. Homes with highly varnished floors must have non-slip area rugs or mats wherever your animal walks or rests frequently.  **Puppy Adoption Policy** To ensure proper house training and socialization, puppies will only be adopted to homes where an adult will not be away more than an hour per day, per month of age of the puppy, up to 6 months. Certain large-breed dogs should not be sterilized prior to 12 - 18 months of age.  If you adopt an intact puppy, you will sign an adoption contract agreeing to have the dog sterilized at your expense at the time your veterinarian recommends. Proof of sterilization must be provided to Mastiffs To Mutts Rescue as soon as the procedure is completed.  If the puppy is not sterilized as required, Mastiffs To Mutts Rescue reserves the right to claim legal ownership of the dog.  For additional information please review our FAQs or contact mastiffstomutts@gmail.com **Mastiffs To Mutts Rescue reserves the right to approve or deny any adoption that occurs through this organization without disclosure.  We reserve the right to make exceptions for special circumstances. **PA Kennel License: 05845   October 4, 2026, 5:43 pm

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Mastiff shelters & rescues in Ephrata, Pennsylvania

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Ephrata, Pennsylvania. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

25.2 miles

York County SPCA

3159 Susquehanna Trail North, York, PA 17406

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

29.1 miles

Mastiffs to Mutts - Eastern PA

Exton, PA 19341

Pet Types: dogs

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Rescue

30.4 miles

Koch's Corsos & Rescues

Manchester, PA 17345

Pet Types: dogs

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Shelter

32.1 miles

Brandywine Valley SPCA - West Chester

1212 Phoenixville Pike, West Chester, PA 19380

Pet Types: cats, dogs

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Rescue

34.2 miles

Mastiffs To Mutts - Central PA

Harrisburg, PA 17109

Pet Types: dogs

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Shelter

35.1 miles

Waiting Under the Willow Foundation - PA Transport

Harrisburg, PA 17112

Pet Types: dogs

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Rescue

42.6 miles

Hinde's Animal Rescue Team

65 S Pennell Road, Media, PA 19063

Pet Types: cats, dogs, farm animals, rabbits, small animals

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Rescue

46.8 miles

Last Chance Ranch Animal Rescue

9 Beck Rd., Quakertown, PA 18951

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Shelter

49.4 miles

Peaceable Kingdom Shelter

1049 MacArthur Road, Whitehall, PA 18052

Pet Types: cats, dogs, rabbits, small animals

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Rescue

49.9 miles

Outcast Rescue

PO Box 12, Catasauqua, PA 18032

Pet Types: dogs

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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