Mastiff Adoption in Lancaster, PA: Mastiff Puppies for Sale in Lancaster, PA

Adopt a Mastiff near you in Lancaster, Pennsylvania

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Lancaster, Pennsylvania

These Mastiffs are available for adoption close to Lancaster, Pennsylvania.

Xena

Mastiff

Female, Young

Marietta, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Xena is a wonderful, gentle dog with a sweet and loving personality. She is amazing with children and enjoys being around people. At 4 years old, she has a calm nature, she likes short walks and is perfectly happy spending most of her day relaxing and napping. Xena loves attention, especially being pet, and is a big fan of snuggling up with her humans. She would make a loyal and affectionate companion in a loving home.

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Baby Girl

Mastiff

Female, 3 yrs 6 mos

Manchester, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Good with cats,

Story

Baby Girl — 3–4 Years Old | 95 lbs | Big Love, Bigger Personality Baby Girl is exactly what her name suggests—a giant sweetheart who believes the world is full of friends she just hasn’t met yet. Found as a stray alongside a French Bulldog, she’s proven to be resilient, loving, and ready to settle into a home of her own. Weighing in at 95 pounds, Baby Girl brings plenty of presence—and plenty of slobber to match! She’s strong on leash and will need someone ready to work on her manners, but she makes up for it with her affectionate nature and eagerness to connect. She’s a social butterfly with no stranger danger, happily greeting new people like long-lost friends. While she hasn’t been kid-tested yet, she does well with cats and other dogs, making her a great candidate for a multi-pet household. At home, Baby Girl is full of personality: She knows how to sit and politely waits for permission before eating She’ll “tell” you when she needs something—with a whine that could mean potty, hunger, or bedtime She keeps a strict bedtime of 8:30–9:00 PM (and expects you to respect it!) She politely asks before hopping into bed She loves her toys… and will scatter them everywhere like adorable little booby traps Baby Girl has not yet been vetted or spayed, but updates are coming soon. If you’re looking for a big, goofy, loving companion who will keep you on a schedule and fill your home with laughter (and a little drool), Baby Girl might just be your perfect match.

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Howie

Mastiff Mixed Breed (Medium)

Male, 8 mos

Manchester, PA

Size

(when grown) -

Details

Story

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Blake

Mastiff Mixed Breed (Medium)

Male, 8 mos

Manchester, PA

Size

(when grown) -

Details

Story

Blake is a Cane Corso puppy we’re already completely smitten with. He’s a handsome little hunk of contradictions—equal parts lazy cuddle bug and playful goofball. Most of the time he’s quiet and laid-back, happily chewing away or lounging nearby, but he’ll find his voice when he thinks something needs to be “handled” (like eagles overhead or mysterious outside noises). Personal space? Not in Blake’s vocabulary. He’s happiest snuggled up as either the big spoon or the little spoon, and he has a special talent for waking you up with gentle face boops and slightly scratchy kisses. Coming from a home with lots of dogs, Blake is very in tune with canine communication. He reads other dogs well and responds beautifully to their cues. He’s much more relaxed and happy with a dog companion around and would love a playful fur sibling, though he’d also be content with a calmer, older dog friend. He’s also currently living in a home with chickens and has been doing well learning to coexist with them under supervision. Blake is still learning about the world and hasn’t had much socialization yet, so his future family will need to continue showing him that new experiences are safe and fun. The good news is he’s been handling everything so far with curiosity and resilience, without any signs of fear-based aggression. He’s house trained, knows “sit,” and takes treats ever so gently. Crate training is coming along nicely, and he’s eager to learn more. Blake truly wants to please and thrives on being close to his people. All in all, he’s a sweet, sensitive, and loyal pup who’s going to make an incredible companion for the right home.

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Bruno PPJ

Mastiff

Male, Young

York transport, PA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

You can fill out an adoption application online on our official website.Thank you for checking out our wonderful orphans. If you would like to find out more please email or call Diane at...diane@ulpr.org or 870-577-3744. Please email us at diane@ulpr.org and request an application.Visit this organization's web site to see any additional information available about this pet.March 15, 2026, 12:14 am

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Johnny

Mastiff Great Dane

Male, Adult

Harrisburg, PA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

PLEASE NOTE! Unless stated otherwise, our dogs and puppies are located in Arkansas, and transported to the north/northeast once adopted. We do occasionally have dogs/puppies placed in foster homes in the north/northeast. In the cases where the pet is somewhere other than Arkansas, it will be noted beside the name of the pet.3/28/26 Located in NY! Johnny is looking for his forever home!! Where are my mastiff lovers? This big boy was adopted from me in January but the adoption just isnt working out. I believe he needs a lot more exercise than he is getting. He is a sweet big baby that would benefit from a strong leader and some training. While here in Arkansas he did fantastic in a daycare setting with many other dogs. He is a young adult, approx 2 years old, and weighs just over 100 lbs. He is currently located in New York. Please email us with any questions. apps.aasr@gmail.com To apply to adopt: https://form.jotform.com/212690945239059Visit this organization's web site to see any additional information available about this pet.Our typical adoption fee for puppies younger than 6 months old is $400, and for older puppies and adults, the usual fee is $350. This includes microchip, spay/neuter, up to date on age appropriate vaccinations, dewormings, flea/tick treatment, and heartworm test (if over 6 months old) as well as heartworm treatment if they test positive. There is a transport fee of $150 per dog, depending on the transporter. We use Pack Leaders Rescue Dog Transport most often, but also use Hearts Transport as well on occasion. Please visit our Facebook page too! https://www.facebook.com/adoptastrayrescueorg For more info regarding adopting, email apps.aasr@gmail.com Thank you for considering one of our rescue babies!March 30, 2026, 6:42 pm

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Mastiff puppies and dogs in Lancaster, Pennsylvania

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Adopt a Mastiff near you in Lancaster, Pennsylvania

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Lancaster, Pennsylvania

These Mastiffs are available for adoption close to Lancaster, Pennsylvania.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Lancaster, Pennsylvania

Mastiff shelters & rescues in Lancaster, Pennsylvania

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics