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Mastiff puppies and dogs in Lancaster, Pennsylvania

Looking for a Mastiff puppy or dog in Lancaster, Pennsylvania? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you Mastiff in cities near Lancaster, Pennsylvania Other pups in Lancaster, Pennsylvania Search for a Mastiff puppy or dog near you Browse Mastiff puppies and dogs in nearby cities Browse related breeds in Lancaster, Pennsylvania Mastiff shelters and rescues in Lancaster, Pennsylvania Learn more about adopting a Mastiff puppy or dog

Adopt a Mastiff near you in Lancaster, Pennsylvania

These Mastiffs are available in Lancaster, Pennsylvania.
We'll also keep you updated on Tuco's adoption status with email updates.
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Tuco

Mastiff

Male, 7 yrs 5 mos
Lancaster, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
Meet Tuco, a gentle giant with a heart as big as his paws! This handsome Mastiff mix has already stolen the hearts of everyone at the shelter. Tuco`s story began when he was abandoned at our shelter after his own passed away, but despite his rocky start, he hasn’t let it dim his sweet and loving spirit.Tuco is a smart boy who knows a few commands like `sit` and is eager to please. Since arriving, he’s been co-housed with another dog—likely his longtime companion—and has shown he can do well with canine friends. With his calm nature and affectionate personality, Tuco is ready to find a family who will give him the love, security, and cozy naps he deserves. If you’ve been looking for a loyal best friend, Tuco might just be your paw-fect match!This pet is available at:BVSPCA - Lancaster2195 Lincoln Hwy ELancaster, PA 17602PA Kennel License #18767

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Or, how about these Mastiffs in cities near Lancaster, Pennsylvania

These Mastiffs are available for adoption close to Lancaster, Pennsylvania.
We'll also keep you updated on Tuco's adoption status with email updates.
Photo of Tuco

Tuco

Mastiff

Male, 7 yrs 5 mos
Lancaster, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
-
Story
Meet Tuco, a gentle giant with a heart as big as his paws! This handsome Mastiff mix has already stolen the hearts of everyone at the shelter. Tuco`s story began when he was abandoned at our shelter after his own passed away, but despite his rocky start, he hasn’t let it dim his sweet and loving spirit.Tuco is a smart boy who knows a few commands like `sit` and is eager to please. Since arriving, he’s been co-housed with another dog—likely his longtime companion—and has shown he can do well with canine friends. With his calm nature and affectionate personality, Tuco is ready to find a family who will give him the love, security, and cozy naps he deserves. If you’ve been looking for a loyal best friend, Tuco might just be your paw-fect match!This pet is available at:BVSPCA - Lancaster2195 Lincoln Hwy ELancaster, PA 17602PA Kennel License #18767

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We'll also keep you updated on YORK-Stray-14649's adoption status with email updates.
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Photo of YORK-Stray-14649

YORK-Stray-14649

Mastiff Mixed Breed (Large)

Female, 3 yrs 9 mos
York, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
-
Story
Found on Penn St in York City

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We'll also keep you updated on Bruno PPJ's adoption status with email updates.
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Bruno PPJ

Mastiff

Male, Young
York transport, PA
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.Thank you for checking out our wonderful orphans. If you would like to find out more please email or call Diane at...diane@ulpr.org or 870-577-3744.   Please email us at  diane@ulpr.org  and request an application.Visit this organization's web site to see any additional information available about this pet.December 11, 2025, 3:57 pm

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We'll also keep you updated on Xaria's adoption status with email updates.
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Xaria

Mastiff Labrador Retriever

Female, Puppy
Wernersville, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, Needs experienced adopter,
Story
I am Xaria. I am 12 weeks old. I have a lot of love to give I love my walks and to play. I'm having some trouble getting into a everyday life with my home, My mom says that her Land Lord does not approve of my staying here, due to...I am having trouble with potty training, mom takes me outside to go, I like to play and stick my nose in the ground and sniff and lick everything, but forget to go to the bathroom... every time, and she takes me inside and I remember I have to go, so I go in her house. I ruined the hardwood floors and their carpet. Mom is on a medical leave for work, and she has been trying her hardest for me, but her landlord said no can do! Mom has to go back to work and is trying to get back on work schedule, but I like to get into everything and I always end up waking her up so she isn't getting the recovery she needs either. I need someone who has TIME AND PATIENCE! I really am a sweetheart, I just was t ment for THIS loving home.

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We'll also keep you updated on Scotty's adoption status with email updates.
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Scotty

Mastiff

Male, Senior
Delta, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, Good with cats, House-trained, Shots are up-to-date,
Story
This is Scotty, hes a purebred English mastiff and he turned eight years old this month. Ive had him since he was 3 months old, hes been my best friend for the past 8 years and it breaks my heart but I have to unexpectedly move for work and I cant take him with me. Hes spent his whole life in a wooded area where he was able to roam and have more freedom than the typical dog does but hes an indoor dog too. Hes very sweet and gentle all hes ever wanted is love and attention, hes great with kids and he grew up in the home with two cats. Hes happy and healthy, although he might be an old man at this point he is still more than capable of running and playing. I would love for him to go to a loving family with a farm or some land where he can live out the rest of his life happily. There is no legal requirement for him to be fixed as the page says at the top. Also I would be willing to partially sponsor his stay with you

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We'll also keep you updated on Jaxon's adoption status with email updates.
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Jaxon

Mastiff

Male, Adult
Stewartstown, PA
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Good with kids, Good with dogs, House-trained, Shots are up-to-date,
Story
He was purchased from a reputable Boerboel breeder. He is DNA tested and that information will be provided to you if you choose to adopt. He is 2 years old, he will be 3 in 2026. In a new home, he will require a lot of time with you as he is a very affectionate dog. Although he is a big dog, he does not require a lot of space. So if you have a condo or an apartment, he will do well there. However, if you have a farm or a lot of space, that would be the ideal place for him. This breed is made to be a farm dog, the name Boerboel translates into farm dog. If I could describe him in a few words, I would say lovable, sweet, and silly. The cons for him are moderate shedding and some allergies.

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Search for a Mastiff puppy or dog

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Lancaster, Pennsylvania.

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Mastiff puppies and dogs in nearby cities

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Related breeds in Lancaster, Pennsylvania

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Mastiff shelters & rescues in Lancaster, Pennsylvania

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Lancaster, Pennsylvania. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Shelter

3.7 miles

Brandywine Valley SPCA - Lancaster

2195 Lincoln Hwy E, Lancaster, PA 17602

Pet Types: dogs

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Shelter

14.9 miles

York County SPCA

3159 Susquehanna Trail North, York, PA 17406

Pet Types: cats, birds, dogs, rabbits, reptiles, small animals

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Rescue

21.9 miles

Pitter Pat Junction, York PA transport

York transport, PA 17403

Pet Types: dogs

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Rescue

26.7 miles

Angies Stray Foundation

Oxford, PA 19363

Pet Types: cats, dogs

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Rescue

29.8 miles

Mastiffs To Mutts - Central PA

Harrisburg, PA 17109

Pet Types: dogs

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Rescue

35.9 miles

Mastiffs to Mutts - Eastern PA

Exton, PA 19341

Pet Types: dogs

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Rescue

38.7 miles

Angel's Retreat

West Chester, PA 19382

Pet Types: dogs

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Rescue

41.2 miles

All 4 Paws Rescue

Malvern, PA 19355

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

47.8 miles

Reach Out Rescue & Resources

P. O. Box 542, Westminster, MD 21158

Pet Types: cats, dogs

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Rescue

48.5 miles

Pitter Pat Junction, MD transport

Towson transport, MD 21204

Pet Types: dogs

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Looking for a specific shelter or rescue?

If you're not seeing what you're looking for, try our shelter and rescue search. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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