Mastiff Adoption in Frederick, MD: Mastiff Puppies for Sale in Frederick, MD

Adopt a Mastiff near you in Frederick, Maryland

These Mastiffs are available in Frederick, Maryland.

*Ripple*

Mastiff

Male, 1 yr 1 mo

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

*No Small ChildrenI am a fun and active guy who will need help learning a few manners. I do know sit. I like to counter surf and I am a very treat motivated guy. I like my food and will take my bowl with me so I can eat without any distractions. I will need an active family who will give me lots of exercise.

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Or, how about these Mastiffs in cities near Frederick, Maryland

These Mastiffs are available for adoption close to Frederick, Maryland.

*Ripple*

Mastiff

Male, 1 yr 1 mo

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Bertha

Mastiff

Female, Adult

Derwood, MD

Size

(when grown) -

Details

Good with dogs, Not good with cats, House-trained, Spayed or Neutered,

Story

Bertha’s Story Meet Bertha, a 3-year-old Mastiff mix with a heart as big as her paws. Bertha’s journey hasn’t been the easiest — she was found abandoned in an apartment after her owners moved out and left her behind. Thankfully, caring neighbors stepped in and did what they could for her before bringing her to a shelter so she could have a real chance at a better life. From there, Bertha went into a temporary foster home while waiting for a full-time foster, and that’s where her true personality began to shine. At first, Bertha was very shy and unsure, but it didn’t take long to see just how much love she had to give. With patience and kindness, she blossomed into the goofy, affectionate girl she truly is. Bertha absolutely loves to play and will never turn down a cozy lap to lay her big head on. She has lived with other dogs and has done well with them, but she would prefer a home without cats. When Bertha was rescued, she was very malnourished, so we are still working on helping her gain healthy weight. Her future family should expect her to be a big girl, likely around 110 lbs once she’s fully filled out — which just means 110 pounds of love. Bertha is looking for a family that will never leave her behind again — one that will give her the security, love, and couch space she deserves. In return, she’ll give you endless loyalty, laughs, and the sweetest snuggles. Could Bertha be the missing piece of your family? If you are interested in applying for Bertha please visit our website at www.keytolionsheart.org! March 9, 2026, 8:11 am

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Alamo

Mastiff Mixed Breed (Medium)

Male, 4 yrs 7 mos

Hagerstown, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

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Tanner

Mastiff Hound (Unknown Type)

Male, 5 yrs 3 mos

Hagerstown, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

He was left behind when his owners moved out. Very affectionate.He looks like a goofy, kind of floppy hound dog as he ambles around. He’s sweet and affectionate. Gets along with most dogs. He’s a little bossy with food especially with a timid dog. Feeding in a crate solves that. Loves his play time in the yard with two stout dogs. Great on a leash. The Adoption Fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea, Tick and Heartworm Treatment and Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. Tanner's adoption fee (if picked up locally in Crossville, Tennessee) is $225. If transport is needed, his adoption fee is $525 (out of state, East Coast, Great Lakes or New England regions).Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to Your Browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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Mark

Mastiff Mixed Breed (Medium)

Male, 2 yrs

Hagerstown, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Spayed or Neutered,

Story

Hello there, I'm Mark! I may be young, but I've got a heart full of love to give. Every morning, I wake up excited for the day ahead. I love playing with my favorite chew toy, but what I really crave is a good game of fetch with a human friend. I'm a quick learner, too! I've already mastered 'sit' and 'stay', and I'm eager to learn more. I promise to be your loyal companion, always ready for an adventure or a cozy nap on the couch. I'm not just looking for a home, I'm looking for a family. Adopt me and let's create a lifetime of wonderful memories together.

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Rah

Mastiff Cane Corso

Female, Adult

Silver Spring, MD

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained, Shots are up-to-date,

Story

Hello everyone, this is Rah. Rah is a 4 year old, 110 lb female, North American Mastiff. Rah loves cuddles, snuggles and couches. Dog parks and playing fetch are her absolute fav! She is VERY gentle with children despite her size. As big as she is she is afraid of her own shadow. Overall she just loves love. She has seasonal allergies, allergic to all poultry and beef. She can eat salmon, pork, and any other type of fish. To keep her allergies at bay, she is on Prednisone. Unfortunately, my husband started school full time along with working full time. I as well work full time and she spends most of her days at home alone. My girl is built for adventures outside not stuck in a small two bedroom apartment.

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These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!

BRANDON

St. Bernard

Male, 6 yrs 9 mos

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered, Shots are up-to-date,

Story

Brandon is a 5 1/2 year old St, Bernard mix. He is a gentle giant. He is a little standoffish when meeting a new person(s). He is very affectionate once he knows you. He loves rubs and scratches. Brandon loves going for walks and checking out the many play yards here at the ranch. He is very mellow. He would thrive in any size family. He follows commands and is eager to please. He loves his treats and is very gentle when taking them. He doesn't like cats. He is one of the sweetest loving dogs. Brandon is eagerly waiting for his forever home. ##1533014##

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Missy - Adoption Pending*

St. Bernard

Female, 3 mos

Frederick, MD

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs,

Story

Current Location: Manchester, MD Hello! My name is Missy! I'm coming to OPH on 3/18. Please check back soon for updates on my personality, and to see adorable new photos. I’m looking for my forever family! Is that with you? If so please click “apply for adoption” or submit an application through the Adopt tab. Let’s get our family started!

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Alice *Adoption Pending*

St. Bernard

Female, 3 mos

Frederick, MD

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs,

Story

Current Location: Manchester, MD Hello! My name is Alice! I'm coming to OPH on 3/18. Please check back soon for updates on my personality, and to see adorable new photos. I’m looking for my forever family! Is that with you? If so please click “apply for adoption” or submit an application through the Adopt tab. Let’s get our family started!

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Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Frederick, Maryland.

Mastiff puppies and dogs in Frederick, Maryland

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Adopt a Mastiff near you in Frederick, Maryland

These Mastiffs are available in Frederick, Maryland.

Or, how about these Mastiffs in cities near Frederick, Maryland

These Mastiffs are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!

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Related breeds in Frederick, Maryland

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Mastiff basics

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Mastiff puppies and dogs in Frederick, Maryland

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Adopt a Mastiff near you in Frederick, Maryland

These Mastiffs are available in Frederick, Maryland.

Or, how about these Mastiffs in cities near Frederick, Maryland

These Mastiffs are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Frederick, Maryland

Mastiff shelters & rescues in Frederick, Maryland

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics