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Mastiff puppies and dogs in Frederick, Maryland

Looking for a Mastiff puppy or dog in Frederick, Maryland? Adopt a Pet can help you find an adorable Mastiff near you.

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Adopt a Mastiff near you in Frederick, Maryland

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Frederick, Maryland

These Mastiffs are available for adoption close to Frederick, Maryland.
We'll also keep you updated on Pluto's adoption status with email updates.
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Pluto

Mastiff Pit Bull Terrier

Male
Brookeville, MD
Size
(when grown) -
Details
Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
PLUTO – A Gentle Giant Who’s Learning What Love Feels Like   Pluto’s story is one of quiet strength, resilience, and hope. When he was first found, Pluto’s body told a heartbreaking story—thin, weak, and covered in the marks of neglect, he had clearly been struggling to survive for far too long. Yet even in his frailest moments, his eyes showed nothing but kindness and a longing to trust again.   With time, care, and steady meals, Pluto has begun to heal. His once fragile frame is filling out, his coat is regaining its shine, and his spirit is blossoming. Today, Pluto is discovering the joy of simple things—soft bedding, full bowls, gentle voices, and the company of people who see him for the beautiful soul he is.   Pluto is a large, calm, and affectionate boy. He moves with quiet confidence and has a gentle presence that draws you in. He gets along well with other dogs, especially those who are respectful and laid-back like he is. He’s not demanding; instead, he enjoys just being near his people, resting his head close by, or soaking up a few moments of peace in the sun.   After everything he’s been through, Pluto deserves a home that will offer him consistency, kindness, and the unconditional love he has always given in return. He is a living reminder that even after hardship, trust and joy can return with patience and care.   Pluto is neutered, microchipped, and up to date on vaccines and preventatives. He will be fully vetted prior to adoption.   Location: Texas (available for transport) Adoption Fee: $350 plus health certificate and transport (if out of state – varies by location) Adoption Process: The adoption contract and fee are finalized prior to transport. All Pep’s Pals Rescue adoptions include a virtual interview and video meet-and-greet.   Pluto is ready to leave his past behind and finally experience the comfort of a loving forever home. Could that be you?   Apply at pepspalsrescue.org/adopt   ##2541025##
We'll also keep you updated on TOBY's adoption status with email updates.
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TOBY

Mastiff

Male, 10 yrs
Derwood, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
Help Toby Find His Forever Home — Before September 17 We have a big goal, and we need your help: let’s get Toby adopted before his one-year anniversary in our care on September 17! For a pup — especially a senior like Toby — a year is a huge portion of their sweet, shorter lives. We can’t let him spend a single day past that milestone still waiting. Despite everything, Toby has stayed happy, loving, and loyal. He’s thriving in his foster home where he gets all the love and belly rubs he could ever hope for. But the truth remains that we have NO idea why on earth Toby has been passed over time and time again. About Toby: Toby is a sweet senior boy who came to our Adoption Center after his previous owners were no longer able to care for him. He’s a gentle giant with a heart of gold and a mellow, lovable personality. Toby is a loyal boy who wants nothing more than a person or family to call his own. He is an EXTREMELY affectionate dog who dreams of nothing more than being with his people, soaking up all the love and attention you can give. Toby is also: Housetrained Sleeps through the night Playful, but low maintenance Good around kids Calm around other dogs His ideal day? Just being with his favorite humans. And if you need a reason to fall in love with him, he’s a world-class kisser. Help us reach our goal — don`t let Toby join the one-year club! More photos of Toby can be cound online here: https://tinyurl.com/AdoptableToby Learn how to adopt Toby
We'll also keep you updated on MOE's adoption status with email updates.
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MOE

Mastiff

Male, 4 yrs 1 mo
Derwood, MD
Size
(when grown) X-Large 101 lbs (46 kg) or more
Details
Spayed or Neutered,
Story
96-Pound Lap Dog in Denial Seeks Human Who Appreciates Galloomies & Premium Snuggle Sessions Meet Moe - a 4-year-old gentle giant who has apparently never looked in a mirror and remains convinced he`s a Chihuahua. Current Life Status: Perfecting the art of the `galloomie` (that`s gallop + zoomie for those unfamiliar with large dog physics)Operating as full-body massage enthusiast (neck, belly, cranium, hind end - he has RANGE)Sporting permanent painted-on smile courtesy of distinguished dark mouth markingsBeing 96 pounds of `I swear I`ll fit in your lap` Professional Qualifications:Walks like a gentleman (your morning coffee won`t even spill)Listens like he`s actually paying attention (because he IS)Good boy manners fully installed at 4 years old (the sweet spot)Takes a moment to assess the vibe before going full joyful goofballWorld-class couch companion for cold winter nightsTreat acceptance: enthusiastic.Massage acceptance: TRANSCENDENT. Ideal Home Requirements:Someone who understands that `gentle giant` isn`t just a phrase - it`s a lifestyleCommitment to full-body massage sessions (he will show you where)Willingness to pretend 96 pounds can fit on a lap (just let him dream)Appreciation for rolling around like a happy weirdoLove of quiet time and quality snuggles The Plot Twist: You`d think a dog this size needs some muscle-bound handler. NOPE. Moe`s a marshmallow who happens to weigh as much as a 7th grader. He`s all sweetness, all gentleness, all `please just love me.` Warning: That painted-on smile? It`s currently shelter decor. Let`s make it real. Moe`s ready. His galloomie legs are ready. His massage-loving body is ready. Is your couch?
We'll also keep you updated on Bear's adoption status with email updates.
Photo of Bear

Bear

Mastiff

Male, Young
Westminster, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Shots are up-to-date,
Story
You can fill out an adoption application online on our official website.All of the animals posted on our site have been temperament tested. While not all are in the immediate area, once we have processed and approved your application, we will move the dog to our adoptive area for you to meet, greet and hopefully adopt. Sometimes we will have more than one application on a dog. That does not mean it automatically goes to another family but you should be aware of the fact that until you are approved and set up for the meet/greet.. the dog could get adopted by another applicant.Hello to all of my fellow Mastiff lovers.   I would like to introduce myself.  My name is Bear and I am the quintessential Mastiff mix of loyalty, playfulness, gentleness, and protectiveness.  I would love to share my home with a human/s who know my breed well, as I am not a novice owner.  I take my job seriously and want you to know when there is a shift in the environment that may need your attention.   I am not a big barker but I am vigilant until you tell me that everything is ok.     I enjoy my crate and it can be a place of calm if I start to take my job too seriously.  I am completely house trained as well.     My strengths:  Smart - I know my 8 basic safety commands in varying capacities - Look, Touch, Sit, Down Stay, Come, Leave it, and Place.  Playful - I love toys, running, jumping, and hanging with my people.  Polite - I am polite on leash unless something fun comes my way like chickens or dogs.   I can become cautious if I see strangers but I move along fine if you tell me everything's ok.   Quiet - I am not a big barker and would prefer watching as things come and go in my environment.  Loyal - I am the most trustworthy guy you will ever know once I know that you are a part of my pack.  I am trusting and enjoy a cuddle once in a while.  I will look for you and want to be with you always.  Trusting - Once you belong to me, I am yours forever.   I am a great sleeper and love my meals.  I enjoy riding in cars.   I enjoy long walks when the weather is not too hot.  I think I would enjoy hiking a lot.     Things I am working on:  Commands - Perfecting my 8 safety commands.  Trusting new things - The more places I go and the more you can let me watch from a distance, the more I can trust new places.  Trusting new people - I need slow introductions with new people who are confident and want to have a relationship.  I am not interested in casual interactions.  I will do best if I know what you expect of me in these situations but I would prefer not to be pushed or 'talked into' socializing.     I will do better with no children or other pets in the home, as I have a hard time sharing the affection.  I was not proofed with cats so I don't know how I feel about them.     General Mastiff traits -  Mastiffs are known for their gentle, calm, and loyal personalities, making them excellent family pets. They are also protective and courageous, exhibiting a natural instinct to guard their families and homes. Despite their imposing size, Mastiffs are often described as 'gentle giants' due to their affectionate and patient nature.    Here's a more detailed look at their personality traits: Loyal and Devoted: Mastiffs form strong bonds with their families and are known for their unwavering loyalty.    Gentle and Affectionate: They are naturally gentle and affectionate, especially with their family members, and enjoy cuddling and close companionship.    Calm and Patient: Mastiffs are generally calm and patient, making them suitable for households with children and other pets, though early socialization and training are still important.    Protective and Courageous: They possess a natural instinct to protect their families and territory, making them excellent watchdogs.    Intelligent and Eager to Please: Mastiffs are intelligent dogs that learn quickly and respond well to positive reinforcement training methods.    Relatively Quiet: While they can be alert and watchful, they are not typically known for excessive barking.    Can be Suspicious of Strangers: It's common for Mastiffs to be wary of strangers, but with proper socialization, they can learn to be more accepting.    If you are interested in Bear, please fill out an application at: https://reachoutrescue.rescuegroups.org/forms/form?formid=4588    Or contact: rorrcanine@gmail.com   *** Click here to sponsor this dog! ***Visit this organization's web site to see any additional information available about this pet.December 6, 2025, 10:18 pm
We'll also keep you updated on Alamo's adoption status with email updates.
Photo of Alamo

Alamo

Mastiff Mixed Breed (Medium)

Male, 4 yrs 3 mos
Hagerstown, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered,
Story
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We'll also keep you updated on Tanner's adoption status with email updates.
Photo of Tanner

Tanner

Mastiff Hound (Unknown Type)

Male, 5 yrs
Hagerstown, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Not good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,
Story
He was left behind when his owners moved out. Very affectionate.He looks like a goofy, kind of floppy hound dog as he ambles around. He’s sweet and affectionate. Gets along with most dogs. He’s a little bossy with food especially with a timid dog. Feeding in a crate solves that. Loves his play time in the yard with two stout dogs. Great on a leash. The Adoption Fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea, Tick and Heartworm Treatment and Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. Tanner's adoption fee (if picked up locally in Crossville, Tennessee) is $225. If transport is needed, his adoption fee is $525 (out of state, East Coast, Great Lakes or New England regions).Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to Your Browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!
We'll also keep you updated on BRANDON's adoption status with email updates.
Photo of BRANDON

BRANDON

St. Bernard

Male, 6 yrs 6 mos
Frederick, MD
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Spayed or Neutered, Shots are up-to-date,
Story
Brandon is a 5 1/2 year old St, Bernard mix. He is a gentle giant. He is a little standoffish when meeting a new person(s). He is very affectionate once he knows you. He loves rubs and scratches. Brandon loves going for walks and checking out the many play yards here at the ranch. He is very mellow. He would thrive in any size family. He follows commands and is eager to please. He loves his treats and is very gentle when taking them. He doesn't like cats. He is one of the sweetest loving dogs. Brandon is eagerly waiting for his forever home. ##1533014##

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Mastiff puppies and dogs in nearby cities

Related breeds in Frederick, Maryland

Mastiff shelters & rescues in Frederick, Maryland

There are animal shelters and rescues that focus specifically on finding great homes for Mastiff puppies in Frederick, Maryland. Browse these Mastiff rescues and shelters below.

Here are a few organizations closest to you:

Rescue

20.9 miles

Pep's Pals Rescue

Brookeville, MD 20833

Pet Types: cats, dogs

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Shelter

21.6 miles

Montgomery County Animal Services and Adoption Center

7315 Muncaster Mill Rd, Derwood, MD 20855

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

22.6 miles

Reach Out Rescue & Resources

P. O. Box 542, Westminster, MD 21158

Pet Types: cats, dogs

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Rescue

25.4 miles

Focus on Cumberland County Animal Safety - MD transport stop

Hagerstown, MD 21740

Pet Types: cats, dogs

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Rescue

25.4 miles

Lucky's Legacy Rescue

Hagerstown, MD 21740

Pet Types: cats, dogs, reptiles, small animals

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Rescue

35.4 miles

Friends Of Homeless Animals

39710 Goodpuppy Lane, Aldie, VA 20105

Pet Types: cats, dogs

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Rescue

36.4 miles

City Dogs Rescue & City Kitties - DC

We do not have a shelter. All of our dogs and cats are in private foster homes., Please complete our application or attend our weekly adoption events to meet one!, Washington, DC 20008

Pet Types: cats, dogs

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Rescue

38.1 miles

God's Dog's Rescue of TX for MD Transport stop

Baltimore, MD 21212

Pet Types: dogs

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Rescue

38.6 miles

Pitter Pat Junction, MD transport

Towson transport, MD 21204

Pet Types: dogs

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Rescue

39.2 miles

Perfectly Paired Pitties (P3)

Washington, DC 20001

Pet Types: dogs

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Want to learn more about adopting a Mastiff puppy or dog?

We've got all the info you need on adopting and caring for a Mastiff puppy. Check out the links below for everything you ever wanted to know about Mastiff puppies and adults.

Mastiff basics

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Where do Mastiffs come from? How many types of Mastiffs are there? From the history of the breed to question about average height, weight and size, brush up on these basic facts about the Mastiff.

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