Mastiff Adoption in Frederick, MD: Mastiff Puppies for Sale in Frederick, MD

Adopt a Mastiff near you in Frederick, Maryland

These Mastiffs are available in Frederick, Maryland.

*Ripple*

Mastiff

Male, 1 yr 1 mo

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

*No Small ChildrenI am a fun and active guy who will need help learning a few manners. I do know sit. I like to counter surf and I am a very treat motivated guy. I like my food and will take my bowl with me so I can eat without any distractions. I will need an active family who will give me lots of exercise.

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Or, how about these Mastiffs in cities near Frederick, Maryland

These Mastiffs are available for adoption close to Frederick, Maryland.

*Ripple*

Mastiff

Male, 1 yr 1 mo

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Corey

Mastiff Labrador Retriever

Male, Adult

Brookeville, MD

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

COREY – A Gentle Giant with a Heart of Gold Corey is the kind of dog who makes an impression the moment you meet him. With his big, handsome frame and soulful eyes, he has the presence of a true gentle giant. But behind that strong exterior is a calm, affectionate dog who simply wants to be near his people. Corey carries himself with a quiet confidence and a peaceful nature. He’s not overly demanding or high-energy—he enjoys the simple things in life like relaxing in the grass, soaking up the sunshine, and spending time beside the people he trusts. His steady temperament and gentle demeanor make him the kind of companion who brings a sense of calm wherever he goes. Despite his large size, Corey is incredibly sweet and easygoing. He does well with other respectful dogs and would thrive in a home that appreciates a big dog with a soft heart. He’s the type of boy who will happily walk by your side and then settle nearby, content just to be part of the moment. Corey is looking for a home that understands big breeds and can give him the love, stability, and space he deserves. In return, he’ll offer unwavering loyalty, companionship, and the quiet comfort that only a devoted dog can provide. Corey is neutered, microchipped, and up to date on vaccines and preventatives. He will be fully vetted prior to adoption. Location: Texas (available for transport) Adoption Fee: $350 plus health certificate and transport (if out of state – varies by location) Adoption Process: The adoption contract and fee are finalized prior to transport. All Pep’s Pals Rescue adoptions include a virtual interview and video meet-and-greet. Corey is ready to find a family who will appreciate his gentle nature and give him the forever home he deserves. Apply to adopt at: pepspalsrescue.org/adopt ##2541025##

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Bertha

Mastiff

Female, Adult

Derwood, MD

Size

(when grown) -

Details

Good with dogs, Not good with cats, House-trained, Spayed or Neutered,

Story

Bertha’s Story Meet Bertha, a 3-year-old Mastiff mix with a heart as big as her paws. Bertha’s journey hasn’t been the easiest — she was found abandoned in an apartment after her owners moved out and left her behind. Thankfully, caring neighbors stepped in and did what they could for her before bringing her to a shelter so she could have a real chance at a better life. From there, Bertha went into a temporary foster home while waiting for a full-time foster, and that’s where her true personality began to shine. At first, Bertha was very shy and unsure, but it didn’t take long to see just how much love she had to give. With patience and kindness, she blossomed into the goofy, affectionate girl she truly is. Bertha absolutely loves to play and will never turn down a cozy lap to lay her big head on. She has lived with other dogs and has done well with them, but she would prefer a home without cats. When Bertha was rescued, she was very malnourished, so we are still working on helping her gain healthy weight. Her future family should expect her to be a big girl, likely around 110 lbs once she’s fully filled out — which just means 110 pounds of love. Bertha is looking for a family that will never leave her behind again — one that will give her the security, love, and couch space she deserves. In return, she’ll give you endless loyalty, laughs, and the sweetest snuggles. Could Bertha be the missing piece of your family? If you are interested in applying for Bertha please visit our website at www.keytolionsheart.org! March 9, 2026, 8:11 am

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Alamo

Mastiff Mixed Breed (Medium)

Male, 4 yrs 6 mos

Hagerstown, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

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Tanner

Mastiff Hound (Unknown Type)

Male, 5 yrs 3 mos

Hagerstown, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, Spayed or Neutered, Shots are up-to-date,

Story

He was left behind when his owners moved out. Very affectionate.He looks like a goofy, kind of floppy hound dog as he ambles around. He’s sweet and affectionate. Gets along with most dogs. He’s a little bossy with food especially with a timid dog. Feeding in a crate solves that. Loves his play time in the yard with two stout dogs. Great on a leash. The Adoption Fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea, Tick and Heartworm Treatment and Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. Tanner's adoption fee (if picked up locally in Crossville, Tennessee) is $225. If transport is needed, his adoption fee is $525 (out of state, East Coast, Great Lakes or New England regions).Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to Your Browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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Mark

Mastiff Mixed Breed (Medium)

Male, 1 yr 11 mos

Hagerstown, MD

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Spayed or Neutered,

Story

Hello there, I'm Mark! I may be young, but I've got a heart full of love to give. Every morning, I wake up excited for the day ahead. I love playing with my favorite chew toy, but what I really crave is a good game of fetch with a human friend. I'm a quick learner, too! I've already mastered 'sit' and 'stay', and I'm eager to learn more. I promise to be your loyal companion, always ready for an adventure or a cozy nap on the couch. I'm not just looking for a home, I'm looking for a family. Adopt me and let's create a lifetime of wonderful memories together.

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These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!

BRANDON

St. Bernard

Male, 6 yrs 9 mos

Frederick, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered, Shots are up-to-date,

Story

Brandon is a 5 1/2 year old St, Bernard mix. He is a gentle giant. He is a little standoffish when meeting a new person(s). He is very affectionate once he knows you. He loves rubs and scratches. Brandon loves going for walks and checking out the many play yards here at the ranch. He is very mellow. He would thrive in any size family. He follows commands and is eager to please. He loves his treats and is very gentle when taking them. He doesn't like cats. He is one of the sweetest loving dogs. Brandon is eagerly waiting for his forever home. ##1533014##

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Mastiff puppies and dogs in Frederick, Maryland

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Adopt a Mastiff near you in Frederick, Maryland

These Mastiffs are available in Frederick, Maryland.

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These Mastiffs are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!

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Mastiff basics

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Mastiff puppies and dogs in Frederick, Maryland

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Adopt a Mastiff near you in Frederick, Maryland

These Mastiffs are available in Frederick, Maryland.

Or, how about these Mastiffs in cities near Frederick, Maryland

These Mastiffs are available for adoption close to Frederick, Maryland.

These pups are in Frederick, Maryland too!

Below are our newest added Mastiffs available for adoption in Frederick, Maryland. To see more adoptable Mastiffs in Frederick, Maryland, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Frederick, Maryland

Mastiff shelters & rescues in Frederick, Maryland

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics