Mastiff Adoption in Maryland: Mastiff Puppies for Sale in Maryland

Adopt a Mastiff near you in Maryland

Below are our newest added Mastiffs available for adoption in Maryland. To see more adoptable Mastiffs in Maryland, use the search tool below to enter specific criteria!

Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 1 mo

Baltimore, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

Learn More

Bertha

Mastiff

Female, Adult

Derwood, MD

Size

(when grown) -

Details

Good with dogs, Not good with cats, House-trained,

Story

Bertha’s Story Meet Bertha, a 3-year-old Mastiff mix with a heart as big as her paws. Bertha’s journey hasn’t been the easiest — she was found abandoned in an apartment after her owners moved out and left her behind. Thankfully, caring neighbors stepped in and did what they could for her before bringing her to a shelter so she could have a real chance at a better life. From there, Bertha went into a temporary foster home while waiting for a full-time foster, and that’s where her true personality began to shine. At first, Bertha was very shy and unsure, but it didn’t take long to see just how much love she had to give. With patience and kindness, she blossomed into the goofy, affectionate girl she truly is. Bertha absolutely loves to play and will never turn down a cozy lap to lay her big head on. She has lived with other dogs and has done well with them, but she would prefer a home without cats. When Bertha was rescued, she was very malnourished, so we are still working on helping her gain healthy weight. Her future family should expect her to be a big girl, likely around 110 lbs once she’s fully filled out — which just means 110 pounds of love. Bertha is looking for a family that will never leave her behind again — one that will give her the security, love, and couch space she deserves. In return, she’ll give you endless loyalty, laughs, and the sweetest snuggles. Could Bertha be the missing piece of your family? If you are interested in applying for Bertha please visit our website at www.keytolionsheart.org! March 9, 2026, 8:11 am

Learn More

*SHEBA

Mastiff

Female, 9 yrs

Upper Marlboro, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Learn More

Precioso

Mastiff

Female, 11 yrs 5 mos

Queenstown, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Precioso is a kind, 11.5-year-old Mastiff that was removed from a rough situation. Despite her difficult life, she has the sweetest disposition to adults and children alike. Although a senior, she still enjoys walking the neighborhood and playing gently with other senior pups. Interested in meeting Precioso? Complete an adoption application today! https://qacmd.seamlessdocs.com/f/adoptionapp

Learn More

Reese's

Mastiff

Female, 5 yrs 1 mo

Queenstown, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Learn More

SERAPHINA

Mastiff

Female, 5 yrs

EASTON, MD

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Seraphina arrived as a stray in rough condition and carried the weight of a hard past. She has spent time healing, building strength, and learning stability. She is ready for a fresh start in a calm, structured home. She needs to be the only pet and requires experienced handlers who understand large breeds and clear boundaries. Older teens only. Seraphina wants consistency, space, and leadership. In return, she offers loyalty, presence, and a chance to watch a dog move from survival to security.

Learn More

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Maryland.

Mastiff puppies and dogs in Maryland

Jump to:

Adopt a Mastiff near you in Maryland

Below are our newest added Mastiffs available for adoption in Maryland. To see more adoptable Mastiffs in Maryland, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Maryland cities

Mastiff shelters & rescues in Maryland

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics

Home

Adopt a Dog

Adopt a Mastiff

Maryland

Mastiff puppies and dogs in Maryland

Jump to:

Adopt a Mastiff near you in Maryland

Below are our newest added Mastiffs available for adoption in Maryland. To see more adoptable Mastiffs in Maryland, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Maryland cities

Mastiff shelters & rescues in Maryland

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics