Mastiff Adoption in O Fallon, MO: Mastiff Puppies for Sale in O Fallon, MO

Adopt a Mastiff near you in O Fallon, Missouri

These Mastiffs are available in O Fallon, Missouri.

BINDI

Mastiff

Female, 2 yrs

St. Peters, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Bindi – Gentle Soul Learning to Shine Bindi is a 2-year-old Boerboel mix who is as sweet as she is shy. She was transferred from another rescue and is still learning to come out of her shell, especially around new people. While nervous in the kennel, Bindi shows her playful and curious side when she’s around other dogs. She enjoys interacting with dogs of all sizes and has shown herself to be submissive yet friendly during introductions, happily coexisting and even playing when she feels safe.Bindi walks well on leash and finds comfort in cozy spaces like dog houses, likely from her time as an outdoor dog. She would thrive in a calm, quiet home with older kids and a patient family who can give her the time and gentle guidance she needs to build trust and confidence. Mental enrichment activities will help Bindi grow into the confident, loving companion she’s meant to be.Bindi is looking for a forever home that understands her gentle, cautious nature and is ready to help her shine.

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Arthur

Mastiff

Male, 3 yrs

St. Peters, MO

Size

(when grown) -

Details

Good with dogs,

Story

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Compton

Mastiff Labrador Retriever

Male, 3 yrs 2 mos

O'Fallon, MO

Size

(when grown) -

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

𝗔𝗗𝗢𝗣𝗧 𝗖𝗢𝗠𝗣𝗧𝗢𝗡 🤍🐷 𝗪𝗲𝗹𝗰𝗼𝗺𝗲 𝘁𝗼 𝘁𝗵𝗲 𝗳𝗮𝗺𝗶𝗹𝘆 Compton 🤍 We promise to find you a 𝒓𝒆𝒂𝒍 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 𝗳𝗮𝗺𝗶𝗹𝘆 this time 🙏 Compton found his way to our city shelter back in January of 2025 as a stray with a collar and leash still attached, but sadly no one came forward 😞 He quickly showed signs of kennel stress, but luckily was sprung by a foster hero, and then what he thought was his furever home…2 months later he was dropped off for dogsitting, the owner blocked the sitter, and never came back for our sweet ham 😭 He was once again adopted again, and later picked up by the Humane Society as a stray and transferred back to CARE. After 𝗮 𝗳𝘂𝗹𝗹 𝘆𝗲𝗮𝗿 𝗼𝗳 𝗯𝗼𝘂𝗻𝗰𝗶𝗻𝗴 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗸𝗲𝗻𝗻𝗲𝗹𝘀 𝗮𝗻𝗱 𝗵𝗼𝗺𝗲𝘀, Compton is FREE of shelter life, decompressing in a home, and snoring like a grown man 😆 (check out the comments for a video!) This level white noise happens when a shelter dog feels like they can finally relax 🥲 The ONLY reason we were able to help Compton is because a 𝗳𝗼𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗼 opened their home 🏡 THANK YOU to all the heroes—you are truly saving a life. All that’s left is to find 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 ♾️👀 _____________________________________________ 𝗚𝗼𝗼𝗱 𝗯𝗼𝘆 𝗾𝘂𝗮𝗹𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝘀𝗼 𝗳𝗮𝗿: • ~3 yr old ~67lbs happy, hefty hog 🐷 • potty/house trained ✔️ • rides well in the car ✔️ • SUPER food motivated—a fast learner! • AFFECTIONATE! he loves a snuggle • DOG FRIENDLY! • NO CATS ❌ • KID FRIENDLY! hasn’t met tiny hoomans but has done well with the ones he has met!

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Or, how about these Mastiffs in cities near O Fallon, Missouri

These Mastiffs are available for adoption close to O Fallon, Missouri.

BINDI

Mastiff

Female, 2 yrs

St. Peters, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

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Arthur

Mastiff

Male, 3 yrs

St. Peters, MO

Size

(when grown) -

Details

Good with dogs,

Story

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Compton

Mastiff Labrador Retriever

Male, 3 yrs 2 mos

O'Fallon, MO

Size

(when grown) -

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

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Ralph BW

Mastiff Mixed Breed (Large)

Male, 1 yr 1 mo

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, Spayed or Neutered,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family He is neutered, microchipped, had recent cherry eye repair and up to date on all vaccines and preventions. Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Luke AG

Mastiff American Pit Bull Terrier

Male, 4 yrs 1 mo

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Not good with cats, Spayed or Neutered,

Story

Hi, I’m Luke, and I’m a big, lovable boy tipping the scales at just over 100 lbs! Don’t let my size fool you—I’m a happy, easygoing pup who just wants to play, explore, and cuddle. I’m all about the good things in life: squeaky toys, water play, long walks, and best of all—snuggle time on the couch. I’m a pro at giving hugs (though I’m working on not jumping up too hard to give them—oops!). I get along great with other dogs and kids, but because of my size and enthusiasm, I’d do best with older children who won’t get accidentally knocked over during playtime. I’m crate trained, housebroken, and walk nicely on a leash—unless there’s a squirrel… then it’s game on! I do have a slight prey drive, so a little guidance goes a long way. If you’re looking for a big-hearted, playful companion to fill your home with love (and maybe take up some space on your couch), I’m your guy. Let’s make forever happen! 🐾 Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Finn AKA Gage JuM

Mastiff Shepherd (Unknown Type)

Male, 7 yrs

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Finn may look like a rockstar with his striking Mastiff–Shepherd good looks, but at heart, he’s a big, soft lovebug. Weighing in at about 60 pounds, Finn has grown into a handsome boy with a beautiful gray and tan coat, soulful eyes, and an even bigger personality. Despite his star-quality appearance, Finn is more of a laid-back, easygoing guy—think Eeyore vibes, but with engines revved and ready to love. From the moment he wakes up, he’s prepared to shower his people with affection… and trust us, it’s A LOT of love! Finn does well with other dogs and does need a slow, proper introductions to new friends—both two-legged and four-legged. Once he knows you, he loves you deeply. He’s happiest when he has a buddy (human or canine) to share his world with. Affection is Finn’s specialty. When someone comes to greet him, he lights up, runs over with enthusiasm, and hands out slobbery kisses and big hugs like they’re backstage passes. His joy is genuine, his heart is huge, and he’s always thrilled to see his people. If you’re looking for a big, lovable, slightly goofy rockstar who will adore you endlessly, Finn is ready to take center stage in your heart. Local adoption only $200 (in TX)

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Mastiff puppies and dogs in O Fallon, Missouri

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Adopt a Mastiff near you in O Fallon, Missouri

These Mastiffs are available in O Fallon, Missouri.

Or, how about these Mastiffs in cities near O Fallon, Missouri

These Mastiffs are available for adoption close to O Fallon, Missouri.

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in O Fallon, Missouri

Mastiff shelters & rescues in O Fallon, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics