Mastiff Adoption in Saint Charles, MO: Mastiff Puppies for Sale in Saint Charles, MO

Adopt a Mastiff near you in Saint Charles, Missouri

These Mastiffs are available in Saint Charles, Missouri.

Wendell

Mastiff Mixed Breed (Large)

Male, 6 yrs 3 mos

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Meet Wendell! 💛 Wendell is a 6-year-old Mastiff mix with a heart as big as his 75-pound frame! This gentle giant was taken in as a stray at just 7 months old and has spent the last several years living peacefully in a home with 15 other dogs of all ages and sizes. He’s truly a pack-friendly boy who gets along with everyone. Unfortunately, his owner had to downsize her dog family, so Wendell came to us. From the moment we met him, it was clear—this boy is pure love! 🥰 He’s chill, affectionate, housebroken, and oh-so-sweet. Wendell absolutely aced his temperament test and showed us just how easygoing and wonderful he is. If you’re looking for a loyal, laid-back companion who will fit right in with your family, Wendell is your guy! This handsome hunk of love is ready to give his heart to a forever home. 🐾 Housebroken 🐾 Dog-friendly with all shapes and sizes 🐾 Big, gentle, and so loving 🐾 Perfect family dog

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Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

Wendell

Mastiff Mixed Breed (Large)

Male, 6 yrs 3 mos

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

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Luke AG

Mastiff American Pit Bull Terrier

Male, 3 yrs 10 mos

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Not good with cats, Spayed or Neutered,

Story

Hi, I’m Luke, and I’m a big, lovable boy tipping the scales at just over 100 lbs! Don’t let my size fool you—I’m a happy, easygoing pup who just wants to play, explore, and cuddle. I’m all about the good things in life: squeaky toys, water play, long walks, and best of all—snuggle time on the couch. I’m a pro at giving hugs (though I’m working on not jumping up too hard to give them—oops!). I get along great with other dogs and kids, but because of my size and enthusiasm, I’d do best with older children who won’t get accidentally knocked over during playtime. I’m crate trained, housebroken, and walk nicely on a leash—unless there’s a squirrel… then it’s game on! I do have a slight prey drive, so a little guidance goes a long way. If you’re looking for a big-hearted, playful companion to fill your home with love (and maybe take up some space on your couch), I’m your guy. Let’s make forever happen! 🐾 Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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WALTER

Mastiff

Male, 5 yrs

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Walter is friendly, outgoing, and his happiness is contagious. He walks well on a leash and seems to be potty trained. He knows sit, loves to play with squeekie toys, and wants all the pets.

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Bellatrix

Mastiff

Female, 8 yrs 1 mo

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Meet Bellatrix – The Gentle Giant with a Harry Potter Twist! Bellatrix may share a name with a famous witch, but don’t worry—she’s all love and loyalty, no dark magic here! This 8-year-old Mastiff is a wise and gentle soul who prefers cuddles over curses and cozy naps over chaos. She absolutely adores people and will happily be your most devoted companion. Bellatrix is potty and crate trained, though she hardly needs her crate it because she’s such a well-mannered lady. Her ideal home? A calm, loving environment where she can relax and feel like the queen of her own Great Hall. She would do best as the only dog in the home. Bellatrix enjoys short strolls, comfy spots like the couch, and being near her favorite humans—she’s basically your very own magical protector. If you’re ready to add a little enchantment (and a lot of love) to your life, Bellatrix is waiting to cast her spell on your heart. Her adoption fee is fully sponsored. Ready to meet Bellatrix? She’s more Hufflepuff than Slytherin—bring her home today! Visit Istodaymydayrescue.org to learn more or fill out an application.

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 1:09 pm

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Mr. Bojangles

Mastiff Mixed Breed (Large)

Male, 3 yrs 5 mos

St. Louis, MO

Size

(when grown) -

Details

Spayed or Neutered,

Story

Meet Mr. Bojangles, a distinguished male dog around three years old, who brings both class and a dash of drama to the table! He would like to clarify that the vocalizations you hear from his kennel are not barking, but rather his intensive opera training in progress! Once he's out, this fancy-pants gentleman is incredibly chill and sweet, and he walks like a pro—no pulling, unless nature is making an urgent call. Mr. Bojangles is a certified foodie who appreciates a good gourmet treat but is just as happy with a classic peanut-butter bone. Basically, he’s a loyal companion who is effortlessly refined and ready to serenade his way into your heart!

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These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

Gracie

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Not good with dogs, Not good with cats, House-trained,

Story

You can fill out an adoption application online on our official website.Gracie was another one that came to us from an Arkansas Shelter basically at the same time as Adolfo. She is another one that is severely underweight and heartworm possible. On June 24th, 2024 she will be receiving one of two back to back injections for HW treatment, the second on the 25th. In a month or went she get to be a healthy weight and under our Vets recommendation she will be spayed. Gracie wishes to be the only pet in the home, there seems to be no negotiating on that front. She requests the full attention of her humans. On the plus side, she loves car rides and won't leave your side on or off leash. If you believe you are the perfect match for our beautiful approximately 5 year old girl please go to our website at mastino-rescue-inc.org and complete a family profile. You won't be disappointed with this girl. Visit this organization's web site to see any additional information available about this pet.November 5, 2024, 10:33 am

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Gianna

Neapolitan Mastiff

Female, Young

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.We partnered with Bull Mastiff Rescuers Inc. who recently saved this unique beauty from being passed around in Michigan. Her double cherry eye has been removed and spay completed, so she is set to find a loving foster home with someone experienced in caring for Neos. We know Gianna plays well with another large male dog but we're still getting to know her personality and specific needs, so stay tuned for more updates. She’s a sweet girl, and we’re committed to finding the perfect match for her. Are you ready to give her the love and care she deserves?Visit this organization's web site to see any additional information available about this pet.December 28, 2024, 12:57 pm

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Anita

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.Miss Anita found herself abandoned in her owners garage went they moved. Several neighborhoods around her rallied to help her. Finally, a couple took her in to try and get her the right home on social media. When that didn't work they came to Mastino Rescue, Inc., to help and find her a home. She has been spayed and on 8/13/24 she had her cherry eye surgery removal. Anita is a great girl, loves her male foster but it took a couple days for her to warm up to her female foster. She will need time to settle into a new home. With slow introductions she started playing with her male foster Neo brother. If you are looking for a beautiful tawny girl, have the time/patience for Anita please go to our website at Mastino-rescue-inc.org and complete a family profile. Anita is being fostered in Arizona but to the perfect home transportation assistance can be provided. Visit this organization's web site to see any additional information available about this pet.November 5, 2024, 10:33 am

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Mastiff puppies and dogs in Saint Charles, Missouri

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Adopt a Mastiff near you in Saint Charles, Missouri

These Mastiffs are available in Saint Charles, Missouri.

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Saint Charles, Missouri

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Adopt a Mastiff near you in Saint Charles, Missouri

These Mastiffs are available in Saint Charles, Missouri.

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Saint Charles, Missouri

Mastiff shelters & rescues in Saint Charles, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics