Mastiff Adoption in Saint Charles, MO: Mastiff Puppies for Sale in Saint Charles, MO

Adopt a Mastiff near you in Saint Charles, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

Ralph BW

Mastiff Mixed Breed (Large)

Male, 1 yr 2 mos

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, Spayed or Neutered,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family He is neutered, microchipped, had recent cherry eye repair and up to date on all vaccines and preventions. Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Luke AG

Mastiff American Pit Bull Terrier

Male, 4 yrs 2 mos

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Not good with cats, Spayed or Neutered,

Story

Hi, I’m Luke, and I’m a big, lovable boy tipping the scales at just over 100 lbs! Don’t let my size fool you—I’m a happy, easygoing pup who just wants to play, explore, and cuddle. I’m all about the good things in life: squeaky toys, water play, long walks, and best of all—snuggle time on the couch. I’m a pro at giving hugs (though I’m working on not jumping up too hard to give them—oops!). I get along great with other dogs and kids, but because of my size and enthusiasm, I’d do best with older children who won’t get accidentally knocked over during playtime. I’m crate trained, housebroken, and walk nicely on a leash—unless there’s a squirrel… then it’s game on! I do have a slight prey drive, so a little guidance goes a long way. If you’re looking for a big-hearted, playful companion to fill your home with love (and maybe take up some space on your couch), I’m your guy. Let’s make forever happen! 🐾 Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Finn AKA Gage JuM

Mastiff Shepherd (Unknown Type)

Male, 7 yrs 1 mo

St Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, Spayed or Neutered,

Story

Finn may look like a rockstar with his striking Mastiff–Shepherd good looks, but at heart, he’s a big, soft lovebug. Weighing in at about 60 pounds, Finn has grown into a handsome boy with a beautiful gray and tan coat, soulful eyes, and an even bigger personality. Despite his star-quality appearance, Finn is more of a laid-back, easygoing guy—think Eeyore vibes, but with engines revved and ready to love. From the moment he wakes up, he’s prepared to shower his people with affection… and trust us, it’s A LOT of love! Finn does well with other dogs and does need a slow, proper introductions to new friends—both two-legged and four-legged. Once he knows you, he loves you deeply. He’s happiest when he has a buddy (human or canine) to share his world with. Affection is Finn’s specialty. When someone comes to greet him, he lights up, runs over with enthusiasm, and hands out slobbery kisses and big hugs like they’re backstage passes. His joy is genuine, his heart is huge, and he’s always thrilled to see his people. If you’re looking for a big, lovable, slightly goofy rockstar who will adore you endlessly, Finn is ready to take center stage in your heart. Local adoption only $200 (in TX)

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Chili Mac is currently enrolled in the 12-week Puppies 4 Parole program through the Mo Department of Corrections. He will graduate around May 1st and will be available for adoption at that time. If you are interested in adopting Chili Mac, please complete an application and the foster parent will contact you. Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter.Visit this organization's web site to see any additional information available about this pet.April 25, 2026, 12:13 am

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Meryl Streep

Mastiff Mixed Breed (Medium)

Female, 2 yrs 2 mos

St. Louis, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,

Story

🩷I learned much about adorable Meryl Streep yesterday as we buddied up and attended CARE’S Adoption Event at “Tower Grove Pride” event. This adorable one and a half year-old pup showed her happy self from the moment she jumped in the car and was the perfect backseat rider. 🩷As we walked to CARE’S tent Meryl walked well on the leash. The event was well attended and this sweet pup was friendly and sweet throughout. As participants of all ages came up to say “Hi” and gave her pets she was gentle to everyone. As other dogs passed she was mostly indifferent being content and enjoying the moment. When this precious girl was tired she laid down and fell fast asleep and stayed like that as the action continued all around her. After her short nap we headed back to the car. This precious, perfect girl made the day’s event fun, happy and totally enjoyable for me her sidekick💕 🩷All I could think is this fabulous pup belongs in a loving home and hopefully soon! Meryl Streep, is a treasure and would be a cherished pup for many families. -Her eye condition is called Cherry Eye and is not serious and will be taken care of by CARES clinic when she’s adopted. 🩷She is at CARE STL for you to meet and possibly fall in love just like me🩷🐾XOXO

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Bagels

Mastiff Mixed Breed (Medium)

Female, 1 yr 6 mos

St. Louis, MO

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

Bagels is an adorable 11-month-old Mastiff mix (we suspect there's a little Boxer in her!) who is the very definition of a tiny lap puppy disguised in a big, beautiful body. This goofy girl has absolutely no clue how big she is, and she'll try to climb right onto your lap to melt you with her big brown eyes and sweet face! Bagels is a true Velcro pup who will follow you everywhere, convinced that your personal space is her personal cuddle zone. But with a face this cute, who needs personal space? She's quite smart, too, and is great motivated, which means she's quick to follow commands. Bagels is reliably house-broken (for the most part!) and loves sleeping comfortably on her own couch, going for walks around the neighborhood, and goofing around in the backyard. She's ready to fill an active home with love, snuggles, and endless laughs!

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These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

Guido

Neapolitan Mastiff

Male, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.Please meet our handsome mahogany boy GUIDO. His coloring is the rarest in the Neapolitan Mastino Breed. Guido and Gino were found roaming in Texas months back. Right before their fate was about to end a local rescue pulled them not knowing what breed they really were. Guido is well socialized, walks great on leash, is house trained and crate trained. He is believed to be approximately 4 to 5 years old. Guido is basically an easy gentlemen that just wants to be close to his humans and a soft bed to crash on. If you are interested in Guido please go to our website at Mastino-Rescue-Inc.org and complete a family profile. Or you can drop us an email at Mastinorescueinc@gmail.com with any questions. Visit this organization's web site to see any additional information available about this pet.March 10, 2026, 12:07 am

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Anita

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.Miss Anita found herself abandoned in her owner's garage when they moved. Several neighbors rallied around her to help her find a new home and family. A couple took her in to try and find her the right home on social media. That didn't work, so they reached out to Mastino Rescue, Inc., to help and find her a home. Anita has been spayed and on 8/13/24 she had her cherry eye surgery removal. Anita is a great girl, loves her previous male foster but it took a couple days for her to warm up to her previous female foster. She will need decompression time to settle into a new home successfully. After slow introductions, she did start playing with her male foster Neo brother when she was in Arizona. If you are looking for a beautiful tawny girl and have the time/patience for Anita, please go to our website at Mastino-rescue-inc.org and complete a family profile. Anita is currently in boarding in Missouri.Visit this organization's web site to see any additional information available about this pet.March 10, 2026, 12:07 am

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Gianna

Neapolitan Mastiff

Female, Young

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.We partnered with Bull Mastiff Rescuers Inc. who saved this unique beauty from being passed around in Michigan. Her double cherry eye has been removed and spay completed, so she is set to find a loving foster home with someone experienced in caring for Neos. She did just have TPLO surgery in December 2025 and is healing well! We know Gianna plays well with another large male dog previously and has been doing well with slow introductions to new people. She’s a sweet girl, and we’re committed to finding the perfect match for her. Are you ready to give her the love and care she deserves?Visit this organization's web site to see any additional information available about this pet.March 10, 2026, 12:07 am

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Mastiff puppies and dogs in Saint Charles, Missouri

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Adopt a Mastiff near you in Saint Charles, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Saint Charles, Missouri

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Adopt a Mastiff near you in Saint Charles, Missouri

We don't see any Mastiffs available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Saint Charles, Missouri

Mastiff shelters & rescues in Saint Charles, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics