Mastiff Adoption in Saint Charles, MO: Mastiff Puppies for Sale in Saint Charles, MO

Adopt a Mastiff near you in Saint Charles, Missouri

These Mastiffs are available in Saint Charles, Missouri.

Lucy

Mastiff

Female, Adult

Saint Charles, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Lucy has been the best dog for our family. We are so sad to have to find her a new home. She is living and cuddly. She is very big but doesn’t know it. She lets our kids climb all over her without a care in the world.

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Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

BONES

Mastiff

Male, 2 yrs 3 mos

Maryland Heights, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Hi, I’m Bones! My journey to the shelter? A classic mix-up. Picture this: I saw a squirrel, gave chase, and somehow ended up leading a conga line at a fancy garden party. Yup, crashed it! After a whirlwind of dance moves and giggles, I was kindly escorted here. I’m a smart, playful guy who can turn any dull moment into a party. Need a dash of joy and a partner in fun? I’m your pup! Let’s make every day a blast together! I am looking for a forever family or a family to love me until my forever family finds me. If you decide to fall head over heels in love and cannot part with me that is okay, too! Please call 314-951-1588 for more information!

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Luke AG

Mastiff American Pit Bull Terrier

Male, 3 yrs 11 mos

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Not good with cats, Spayed or Neutered,

Story

Hi, I’m Luke, and I’m a big, lovable boy tipping the scales at just over 100 lbs! Don’t let my size fool you—I’m a happy, easygoing pup who just wants to play, explore, and cuddle. I’m all about the good things in life: squeaky toys, water play, long walks, and best of all—snuggle time on the couch. I’m a pro at giving hugs (though I’m working on not jumping up too hard to give them—oops!). I get along great with other dogs and kids, but because of my size and enthusiasm, I’d do best with older children who won’t get accidentally knocked over during playtime. I’m crate trained, housebroken, and walk nicely on a leash—unless there’s a squirrel… then it’s game on! I do have a slight prey drive, so a little guidance goes a long way. If you’re looking for a big-hearted, playful companion to fill your home with love (and maybe take up some space on your couch), I’m your guy. Let’s make forever happen! 🐾 Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Compton

Mastiff Labrador Retriever

Male, 3 yrs

O'Fallon, MO

Size

(when grown) -

Details

Good with dogs, House-trained, Spayed or Neutered,

Story

𝗔𝗗𝗢𝗣𝗧 𝗖𝗢𝗠𝗣𝗧𝗢𝗡 🤍🐷 𝗪𝗲𝗹𝗰𝗼𝗺𝗲 𝘁𝗼 𝘁𝗵𝗲 𝗳𝗮𝗺𝗶𝗹𝘆 Compton 🤍 We promise to find you a 𝒓𝒆𝒂𝒍 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 𝗳𝗮𝗺𝗶𝗹𝘆 this time 🙏 Compton found his way to our city shelter back in January of 2025 as a stray with a collar and leash still attached, but sadly no one came forward 😞 He quickly showed signs of kennel stress, but luckily was sprung by a foster hero, and then what he thought was his furever home…2 months later he was dropped off for dogsitting, the owner blocked the sitter, and never came back for our sweet ham 😭 He was once again adopted again, and later picked up by the Humane Society as a stray and transferred back to CARE. After 𝗮 𝗳𝘂𝗹𝗹 𝘆𝗲𝗮𝗿 𝗼𝗳 𝗯𝗼𝘂𝗻𝗰𝗶𝗻𝗴 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗸𝗲𝗻𝗻𝗲𝗹𝘀 𝗮𝗻𝗱 𝗵𝗼𝗺𝗲𝘀, Compton is FREE of shelter life, decompressing in a home, and snoring like a grown man 😆 (check out the comments for a video!) This level white noise happens when a shelter dog feels like they can finally relax 🥲 The ONLY reason we were able to help Compton is because a 𝗳𝗼𝘀𝘁𝗲𝗿 𝗵𝗲𝗿𝗼 opened their home 🏡 THANK YOU to all the heroes—you are truly saving a life. All that’s left is to find 𝗳𝘂𝗿𝗲𝘃𝗲𝗿 ♾️👀 _____________________________________________ 𝗚𝗼𝗼𝗱 𝗯𝗼𝘆 𝗾𝘂𝗮𝗹𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝘀𝗼 𝗳𝗮𝗿: • ~3 yr old ~67lbs happy, hefty hog 🐷 • potty/house trained ✔️ • rides well in the car ✔️ • SUPER food motivated—a fast learner! • AFFECTIONATE! he loves a snuggle • DOG FRIENDLY! • NO CATS ❌ • KID FRIENDLY! hasn’t met tiny hoomans but has done well with the ones he has met!

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Lucy

Mastiff

Female, Adult

Saint Charles, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

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WALTER

Mastiff

Male, 5 yrs 1 mo

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Walter is friendly, outgoing, and his happiness is contagious. He walks well on a leash and seems to be potty trained. He knows sit, loves to play with squeekie toys, and wants all the pets.

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Chili Mac

Mastiff

Male, Puppy

St Louis, MO

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Meet Chili Mac! This 11-month-old Cane Corso is a big, lovable goofball with a heart as giant as his paws! Chili Mac is equal parts cuddle bug and class clown — he’ll make you laugh one minute and melt into your lap the next. He can be a little shy when meeting new people, but once he decides you’re cool, he’s all in! He’s great with dogs big and small (seriously — from 6 lbs to 120 lbs!), crate and potty trained, and already knows some basic commands. Due to Chili Mac's size and clumsiness, he would do best in a home with older children. He would also be best with someone who has breed/guardian experience given some mouthy behaviors which are normal for the breed. Chili Mac would love an active home with another dog friend or a human adventure buddy. Whether you’re hiking, road-tripping, or just lounging on the couch- as long as you don’t mind a little drool, he’s ready to be your ride-or-die! If interested, please complete the Adoption Application on our website at www.NeedyPaws.org and we will contact you. Adopters must live within an hour’s drive of St. Louis, MO. Our $295 adoption fee includes up-to-date vaccinations, heartworm testing and preventative, spay/neuter and microchip. We are a 100% foster-based rescue and all of our dogs live in approved foster homes. We are dedicated to finding the best Forever Homes, and will perform home visits and conduct veterinarian and reference checks for each potential adopter. Visit this organization's web site to see any additional information available about this pet.December 26, 2025, 1:09 pm

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These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

Anita

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.Miss Anita found herself abandoned in her owner's garage when they moved. Several neighbors rallied around her to help her find a new home and family. A couple took her in to try and find her the right home on social media. That didn't work, so they reached out to Mastino Rescue, Inc., to help and find her a home. Anita has been spayed and on 8/13/24 she had her cherry eye surgery removal. Anita is a great girl, loves her previous male foster but it took a couple days for her to warm up to her previous female foster. She will need decompression time to settle into a new home successfully. After slow introductions, she did start playing with her male foster Neo brother when she was in Arizona. If you are looking for a beautiful tawny girl and have the time/patience for Anita, please go to our website at Mastino-rescue-inc.org and complete a family profile. Anita is currently in boarding in Missouri.Visit this organization's web site to see any additional information available about this pet.January 19, 2026, 8:06 pm

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Gracie

Neapolitan Mastiff

Female, Adult

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Not good with dogs, Not good with cats, House-trained,

Story

You can fill out an adoption application online on our official website.Gracie came to us from an Arkansas Shelter basically at the same time as Adolfo. She was also severely underweight and heartworm positive. Gracie has successfully completed her heartworm treatment and has been spayed. Gracie wishes to be the only pet in the home and there seems to be no negotiating on that front from her. She requests the full attention of her humans. On the plus side, she loves car rides and won't leave your side whether she is on or off leash. She never disappoints! If you believe you are the perfect match for our beautiful approximately 5 year old girl, Gracie, please go to our website at mastino-rescue-inc.org and complete a family profile. Visit this organization's web site to see any additional information available about this pet.January 19, 2026, 8:29 pm

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Gianna

Neapolitan Mastiff

Female, Young

St. Louis, MO

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

You can fill out an adoption application online on our official website.We partnered with Bull Mastiff Rescuers Inc. who saved this unique beauty from being passed around in Michigan. Her double cherry eye has been removed and spay completed, so she is set to find a loving foster home with someone experienced in caring for Neos. She did just have TPLO surgery in December 2025 and is healing well! We know Gianna plays well with another large male dog previously and has been doing well with slow introductions to new people. She’s a sweet girl, and we’re committed to finding the perfect match for her. Are you ready to give her the love and care she deserves?Visit this organization's web site to see any additional information available about this pet.January 19, 2026, 9:11 pm

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Mastiff puppies and dogs in Saint Charles, Missouri

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Adopt a Mastiff near you in Saint Charles, Missouri

These Mastiffs are available in Saint Charles, Missouri.

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Saint Charles, Missouri

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Adopt a Mastiff near you in Saint Charles, Missouri

These Mastiffs are available in Saint Charles, Missouri.

Or, how about these Mastiffs in cities near Saint Charles, Missouri

These Mastiffs are available for adoption close to Saint Charles, Missouri.

These pups are in Saint Charles, Missouri too!

Below are our newest added Mastiffs available for adoption in Saint Charles, Missouri. To see more adoptable Mastiffs in Saint Charles, Missouri, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in nearby cities

Related breeds in Saint Charles, Missouri

Mastiff shelters & rescues in Saint Charles, Missouri

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog?

Mastiff basics

Mastiff basics