Great Dane Adoption in Massachusetts: Great Dane Puppies for Sale in Massachusetts

Adopt a Great Dane near you in Massachusetts

Below are our newest added Great Danes available for adoption in Massachusetts. To see more adoptable Great Danes in Massachusetts, use the search tool below to enter specific criteria!

Twiggy

Great Dane

Female, Young

Osterville, MA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, House-trained,

Story

We are looking for a loving new home for our wonderful, 3.5 year old, female Great Dane. She is sweet, affectionate, well trained, and loves people. She is especially good with children and enjoys being part of the family. She loves lying on the couch and cuddling with you.She is house trained, crate trained, e-collar trained, and walks beautifully on a leash, staying right by your side. She is not food aggressive and is up to date on vaccinations. She is also spayed and has had a gastropexy.Although she has so many wonderful qualities, she can be unpredictable around other dogs, particularly when she is on a leash. Other dogs cannot be allowed to approach her during walks. For this reason, she would do best as the only dog in a home and an owner who understands how to manage dog interactions responsibly.She is a truly special dog, and our priority is finding an experienced, loving home where she can feel safe, secure, and thrive.

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Nyx

Great Dane

Male, 8 mos

North Reading, MA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

*Name: Nyx*Age: 9 months (born approximately December 2025)*Current Weight: 74 lbs*Rescued from: Puerto Rico*Adoption fee: $650 (includes $50 refundable spay/neuter deposit and $50 refundable positive training commitment deposit) Meet Nyx! Nyx is a handsome 8-month-old Great Dane mix making his way from Puerto Rico and looking for his forever home! At 74 pounds and still just a pup, Nyx is definitely a big guy, but don’t let his size fool you — he is incredibly well-mannered! He’s also great with dogs, cats and kids, making him a wonderful fit for all kinds of families. Nyx is still young and has plenty of growing and learning ahead of him, but he’s already showing what a wonderful dog he is. He’s ready to leave island life behind and start his next chapter with a family of his very own. If you’re a big-dog lover looking for a sweet, well-mannered young guy who gets along with just about everyone, Nyx may be the one for you! All of our dogs come with a 7-week group Beginner course at Bark n' Roll in North Reading included with adoption. If you are not local to North Reading you may opt for an included virtual private session with a certified positive trainer with Bark n' Roll. To apply to adopt, fill out an application at www.rescueallthedogs.org/adopt. Please note that RnR is a volunteer-based organization. While volunteers review applications as quickly as possible, it is helpful if you review the following information about our adoption process:LISTED BREED(S) & AGE: We are taking our best guess on age, breed, and size when fully grown, based on the dog's physical appearance and what we might have learned about one or both parents. We rarely know a dog's exact age or full breed mix of dogs, as our information is usually limited.RNR’s ADOPTION PROCESS: The first step in adopting or meeting one of our adoptable pups is to fill out an application at www.rescueallthedogs.org/adopt. Once we receive your application, one of our volunteers will contact you, review our adoption process, and answer any additional questions you may have. It is important to note that we do not go on a first-come-first-serve basis for adoptions but on the best fit for a family and, most importantly, the dog.MEETING ADOPTABLE DOGS: Meet and greets will not be scheduled until your adoption application is submitted and reviewed.APPLYING ONLINE: When completing an application, please do so from a computer (not a mobile device); make sure you answer ALL the questions in as much detail as possible and that you receive a confirmation email. ##2829946##

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Bonnie

Great Dane

Female, Adult

Boston, MA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, Needs experienced adopter, House-trained,

Story

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Princess

Great Dane

Female, Young

Holyoke, MA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, Good with cats, Needs experienced adopter,

Story

She is s a loving dog. She loves head scratches and running outside just like any other dog. She is a big breed and needs a lot of love, attention and training. She deserves a home that has time for her to grow and prosper. She was born some time in December ‘24 I’ve had her since March ‘25. She is still a puppy with a big heart. I have a busy schedule and she needs more time than I have for her right now. I moved, so I’ve had to work more to make ends meet. She deserves the whole world. She still has trouble making it outside on time to use the bathroom. She has accidents in her cage, but has been improving slowly. She gets along with other dogs, she is very playful. She gets along with my house cat. She’s just recently finding her “voice”. She’s now due for her rabies shot after a year. If anyone can provide the space, time, financial stability and training she needs please reach out. She needs a lot of help I haven’t been able to provide properly. Thank you.

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Buddy

Great Dane/Rhodesian Ridgeback

Male, 3 yrs 5 mos

Gloucester, MA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

Meet Buddy! Buddy is a sweet, quirky 3-year-old who has a few thoughts about how life should be organized. He is a pretty mellow guy who enjoys hanging out with his people, getting affection, and generally taking it easy, provided of course that the day proceeds according to plan. Buddy is a creature of routine. He likes knowing what’s coming next, and unexpected changes to his schedule can be a bit... inconvenient, in Buddy’s opinion. He is also a very devoted people-dog who likes to keep his humans close. He doesn`t mind doing things and would probably be quite happy to tag along with you for the day, whether that means running errands, going for an adventure, or possibly even heading to work. He just isn`t a big fan of being left behind. Buddy has lived with dogs, cats, a bird, and people of all ages, and he has spent time at Tide Pool Pet Services working on his skills. He is looking for a home where someone is around often, appreciates a predictable routine, and doesn`t mind having a dog with some very specific ideas about how the household should operate. A securely managed yard will also be important, as Buddy has demonstrated some entrepreneurial tendencies when it comes to finding his own way out. He is not for everyone, but we have a feeling there is someone out there who will find his particular brand of weirdness completely charming. Buddy is part sweetheart, part routine enthusiast, and 100% himself, and we think the right person is going to love him exactly that way. Buddy is part of our Extended Stay adoption promotion, meaning he has a lower adoption fee and goes home with a post-adoption training reimbursement plus six months of heartworm and flea & tick prevention to help ensure a great new start. Interested in Buddy? Send in your application to: capeannanimalaid.org/dogapp

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Great Dane puppies and dogs in Massachusetts

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Adopt a Great Dane near you in Massachusetts

Below are our newest added Great Danes available for adoption in Massachusetts. To see more adoptable Great Danes in Massachusetts, use the search tool below to enter specific criteria!

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Great Dane puppies and dogs in Massachusetts

Jump to:

Adopt a Great Dane near you in Massachusetts

Below are our newest added Great Danes available for adoption in Massachusetts. To see more adoptable Great Danes in Massachusetts, use the search tool below to enter specific criteria!

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in Massachusetts cities

Great Dane shelters & rescues in Massachusetts

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog ?

Great Dane information

Great Dane basics