Great Dane Adoption in Middletown, OH: Great Dane Puppies for Sale in Middletown, OH

Adopt a Great Dane near you in Middletown, Ohio

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Middletown, Ohio

These Great Danes are available for adoption close to Middletown, Ohio.

Rex

Great Dane

Male, 1 yr 1 mo

Springboro, OH

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs,

Story

Rex is a gentle giant with a heart just as big as his paws. This handsome Great Dane brings together the perfect mix of playful energy and laid-back charm, making him an easy dog to love. Rex absolutely adores people and thrives on attention. Whether he’s leaning in for affection (classic Dane style!) or happily greeting new friends, he makes everyone feel special. And when it comes to other dogs, Rex is just as enthusiastic — he loves having canine buddies to romp around with or simply hang out beside. Despite his impressive size, Rex is all sweetness. He’s the kind of dog who will happily join you for adventures and then stretch out for a cozy nap at your feet at the end of the day. If you’re looking for a loyal, loving companion who gets along with everyone he meets, Rex the Dane is ready to fill your home — and your heart — in the best way possible.

Learn More

Deion

Great Dane

Male, Puppy

Germantown, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained, Spayed or Neutered,

Story

Meet Deion, a lovable 35-pound Great Dane mix puppy who's just 4.5 months old! With his silly, goofy personality, Deion is always ready to bring a smile to your face. His clumsy antics make every day an adventure, whether he's tripping over his own paws or playfully tumbling into his toys. Deion adores people and gets along wonderfully with other dogs, making him the perfect companion for playdates and snuggles alike. He’s already crate trained, showing off his smart side, and is potty trained! Such a good boy! With his playful spirit and affectionate nature, Deion is sure to steal your heart! All of our dogs are spayed or neutered, up to date on age appropriate vaccinations, microchipped and if over 6 months of age, heartworm tested and on heartworm preventative in their foster home. We require an approved application to meet any of our dogs. We do not have a shelter location and will not arrange a meeting without an approved application. We strive to make sure the bios provided for our dogs are complete and accurate; we do understand that mistakes happen, however, so if you absolutely cannot find the answer to your question in the dog's bio, you can contact us for more information. We require a home visit for each dog we adopt out, so we adopt within a 2 hour radius of Dayton, OH. If you are outside of this radius, we encourage you to contact your local rescue or shelter. March 16, 2026, 9:54 pm

Learn More

Archie

Great Dane

Male, Adult

West Chester, OH

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Not good with kids, Good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Our family adopted Archie as a puppy and we have loved watching him grow up. He will be 3 years old as of March 26. He is such a sweetheart and loves to snuggle up to his humans. He has a lot of personality and loves to play with his toys.. he always has a stuffy in his mouth! He would be best in a home without small children as he seems to get nervous around kids he doesn’t know. Archie gets along well with other dogs, but probably not those under 50lbs and not cats. He does resource guard his food. Rehoming him does feel like losing a member of the family, but I lost my husband a year ago and it’s just been too difficult for me to care for him along with my five children alone.

Learn More

Butkus

Great Dane Mixed Breed (Large)

Male, 5 yrs 6 mos

Farmersville, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Spayed or Neutered,

Story

Meet Butkus! Butkus is a 5-year-old Great Dane mix with a heart as big as his paws. This handsome boy is the total package—friendly, gentle, and ready to be your loyal companion. He absolutely loves people, especially kids, and would fit right in with a family looking for a calm, affectionate dog. Butkus is well-mannered and easy to handle. He walks nicely on a leash, making daily strolls a pleasure rather than a chore. He’s also housebroken, so he’ll settle into his new home with ease. Butkus already knows some basic commands and does a great job listening, which shows just how smart and eager to please he is. Whether you’re looking for a walking buddy, a couch companion, or a loving family dog, Butkus is ready to fill that role. All he needs now is a forever home where he can share his love and gentle spirit. Come meet Butkus—you might just find your perfect match!

Learn More

Byndi

Great Dane Labrador Retriever

Female, 2 yrs 2 mos

Kettering, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained, Spayed or Neutered, Shots are up-to-date,

Story

Byndi is a 2-year-old female presumed to be a Dane mix. She comes to us as a stray found by one of our fosters. A sleek black coat and mesmerizing dual eye color, she is a beautiful young lady. She is also a lady with manners, waiting patiently for food and gently taking treats, and is potty and crate trained. Byndi is Young and very playful, often happily carrying toys around with her. She seems to be an all-weather dog, having a grand old time playing in the snow and takes any opportunity to stretch her legs and have a good run. A family with a larger yard or an active lifestyle would be a lovely fit. Exercise will be important. She has had limited experience with cats, but has had good temperament thus far. Byndi has warmed up to people faster than she has to dogs. She seems to be intimidated by larger or more dominant dogs, but has had more playful and relaxed encounters with smaller companions. A home with smaller children might be on the overwhelming side for Byndi, older children would be a better pairing. She is still young and learning boundries. She is still very much in the middle of decompression and has attached herself to her foster mom quickly. Byndi seems to be protective of her person and will need slow introduction to house guests until trust is earned and a routine is built. We are working with a trainer to help ease her anxiety with all the change and finding positive ways to build trust and love. Showing Byndi that the past doesn't have to define her future, and that kindness exists in the world. Byndi has a lot of love and wiggles to give. We believe once Byndi understands she is safe and comfortable, she has all the potential to be the best companion for years to come. All Paw Patrol Dayton animals come snip, chipped, tested and treated. Her adoption fee is $285 to help keep the love train rolling. All of our animals are vaccinated, micro-chipped and spayed/neutered before being adopted.

Learn More

Sierra

Great Dane

Female, Young

Dayton, OH

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with dogs, Not good with cats, Needs experienced adopter, House-trained,

Story

I did get Sierra from a breeder when she was 8 weeks old. I had no intention of ever rehoming her however I have not been able to find employment since November 2024 and I will be moving in with my son actually the end of next week. I’ve been trying since October of last to rehome her with no luck. She is a very loving dog, loves to fetch, enjoys being outside, is crate, trained, treat, responsive, and as many of the goofy things that great Danes do. I am desperate to find her a loving family. She has not been spayed and I have not been able to get the funds together to do so so I am concerned she will go into a heat cycle, which makes her not as friendly with other dogs. Normally, she does fine with them, however. Will provide more information. Should you be interested.

Learn More

Use the search tool below to browse adoptable Great Dane puppies and adults Great Dane in Middletown, Ohio.

Great Dane puppies and dogs in Middletown, Ohio

Learn More:

Adopt a Great Dane near you in Middletown, Ohio

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Middletown, Ohio

These Great Danes are available for adoption close to Middletown, Ohio.

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in Middletown, Ohio

Great Dane shelters & rescues in Middletown, Ohio

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog?

Great Dane basics

Great Dane basics

Home

Adopt a Dog

Adopt a Great Dane

Ohio

Middletown

Great Dane puppies and dogs in Middletown, Ohio

Learn More:

Adopt a Great Dane near you in Middletown, Ohio

We don't see any Great Danes available for adoption right now, but new adoptable pets are added every day. Try a different search below!

Or, how about these Great Danes in cities near Middletown, Ohio

These Great Danes are available for adoption close to Middletown, Ohio.

Search for a Great Dane puppy or dog

Great Dane puppies and dogs in nearby cities

Related breeds in Middletown, Ohio

Great Dane shelters & rescues in Middletown, Ohio

Looking for a specific shelter or rescue?

Want to learn more about adopting a Great Dane puppy or dog?

Great Dane basics

Great Dane basics