Mastiff Adoption in Indiana: Mastiff Puppies for Sale in Indiana

Adopt a Mastiff near you in Indiana

Below are our newest added Mastiffs available for adoption in Indiana. To see more adoptable Mastiffs in Indiana, use the search tool below to enter specific criteria!

Chadwick

Mastiff

Male, 2 yrs

Fishers, IN

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Story

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Nash

Mastiff/Coonhound

Male, 5 mos

MUNCIE, IN

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Nash is a 5-month-old Mastiff mix with a big heart and an even bigger future ahead of him! This handsome boy is still just a puppy, but he’s already showing what a wonderful family companion he’ll be. According to his previous owner, Nash is great with kids, does well with other dogs, and is already housebroken — talk about a smart pup! He has that classic Mastiff sweetness paired with playful puppy energy, making him the perfect mix of gentle and fun. Nash is ready to grow up in a loving home that will continue his training and help him become the amazing, loyal best friend he’s meant to be. If you’re looking for a family-friendly pup with lots of love to give, Nash could be your guy! 🐶💛

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Brutus

Mastiff

Male, 9 yrs

Kokomo, IN

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, Good with cats, House-trained,

Story

Hello everyone! Meet Brutus! Brutus is a 9 year old mastiff we took from a very crowded shelter who needed to open kennels. We don’t typically spring for the big dogs but after the shelter exhausted all large breed rescues which were sadly full, it was hard not to take a look at his amazing smile and his beautiful bright eyes and not welcome him in, so we did just that. His foster family said he is absolutely excellent with his house manners. He weighed 125 pounds when we neutered him and while he may be a senior he sure doesn’t exude that attitude. He is bright and full of life. Brutus is very intelligent, a total slobber box, excellent with the 11 year old kiddo in the home, all of the dogs, and completely ignores the kitties. He does require one small treat to get him in his crate but that’s pretty typical to be slightly stubborn at this size HAHA. Anyway, once an application is filled out we would be happy to connect you with us foster families so you can ask all the questions and get tons of extra pictures and videos! He is a wonderful boy and we hope his agent size does not limit his adoption. Adoption donation fee is $50 or reasonable donation which it is tax-deductible and goes towards the care of homeless pets with Unchained Souls Canine Rescue. To expedite the adoption process you can send us a message at Unchained Souls Canine Rescue on Facebook to request an application or you can email us at unchainedsoulscaninerescue@yahoo.com and we will happily send you one! All Unchained Souls Canine Rescue animals are fully vetted: *Spayed/Neutered *Shots updated *Micro-chipped *Heart-worm checked and on prevention *On Flea and Tick Prevention You only need to see your vet for a “meet n greet” of your new family member and to turn in their medical records.

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Whiskey

Mastiff

Female, 1 yr 2 mos

Angola, IN

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

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Special Needs

Roxie

Mastiff/Mixed Breed (Medium)

Female, 4 yrs 5 mos

Indianapolis, IN

Size

(when grown) -

Details

Good with cats, Needs special attention,

Story

Roxie is a sweet, shy girl currently thriving in her foster home. She warms up slowly, but once she trusts you, she’s loving, goofy, and very treat-motivated. She’s done well with easygoing dogs and is still learning how to understand cats. New people and places can be overwhelming for her, so she’ll need a patient home that lets her settle at her own pace. Because she startles easily and doesn’t enjoy close handling, she’d do best in an adult-only home or one with older teens. Roxie loves car rides, does great for baths, and has some ongoing medical needs like hip dysplasia and skin/knee issues, which are managed with joint supplements and a gentle diet. If you’re looking for a loyal companion who blossoms with kindness and routine, Roxie could be the perfect match! Roxie is currently in foster—if you’d like to see if she’s a good fit, just submit an application and we’ll review it to set up a meet-and-greet with her foster. *Roxie has been waiting for her forever home for over 100 days, which makes her a Featured Pet! That means her adoption fee is completely waived—all she needs now is the right family to take her home!

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TIGER - SOS RESCUE

English Mastiff

Male

Morgantown, IN

Size

(when grown) -

Details

Story

TIGER! Mastiff mix, 14 months old, brindle Contact: savingoutstandingsouls@gmail.com January 29, 2026, 5:11 pm

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Below are our newest added Mastiffs available for adoption in Indiana. To see more adoptable Mastiffs in Indiana, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Indiana

Jump to:

Adopt a Mastiff near you in Indiana

Below are our newest added Mastiffs available for adoption in Indiana. To see more adoptable Mastiffs in Indiana, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Indiana cities

Mastiff shelters & rescues in Indiana

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics