Mastiff Adoption in Virginia: Mastiff Puppies for Sale in Virginia

Adopt a Mastiff near you in Virginia

Below are our newest added Mastiffs available for adoption in Virginia. To see more adoptable Mastiffs in Virginia, use the search tool below to enter specific criteria!

Daphne (B)

Mastiff

Female, 2 yrs 2 mos

Roanoke, VA

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

Meet Daphne, a sweet 2-year-old mastiff mix ready to leave her rough past behind and start her next chapter with a family of her own. This loving girl has a heart full of love and would be happiest with a human who enjoys adventures, long walks, and maybe even a fully fenced yard where she can stretch her legs and play. Daphne is affectionate, loyal, and always ready to be by your side, whether you’re out exploring or curled up on the couch together. She knows her basic commands and is eager to train! Come meet this beautiful girl today!

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PUMPKIN

Mastiff

Female, Young

Harrisburg, VA

Size

(when grown) X-Large 101 lbs (46 kg) or more

Details

Good with kids, Good with dogs, House-trained,

Story

PUMPKIN IS IN HER FOSTER HOME IN MEMPHIS, TN, AND WILL BE TRANSPORTED TO VA ONCE ADOPTED! Pumpkin is a big, beautiful Mastiff mix who is about one year old and weighs around 115 pounds. She’s a loving, playful girl who enjoys treats and spending time outside. Pumpkin can be a little shy at first, so her adopters will need to be patient and give her time to feel comfortable. Once she warms up, she’s incredibly sweet and affectionate. She is crate trained and housebroken, and she walks well on a leash. Pumpkin enjoys walks around the neighborhood and trips to the park. After a day of fun, she’s happiest snuggling on the couch with her people. Despite her big size, Pumpkin is calm, quiet, and gentle — the perfect companion for someone looking for a loyal and loving friend. She is fully vetted. Vetting includes spay/neuter, microchip, rabies and all dog vaccinations. Her adoption fee of $600 includes the transport to VA. We use a licensed and registered USDA transport company that will bring Pumpkin up north to her new family. You can apply to adopt her today! If you have any questions, please email us at: newbeginnings_animalrescue@yahoo.com You can apply to adopt Pumpkin here: www.newbeginningsanimalrescue.net THANK YOU FOR CONSIDERING ADOPTING A RESCUED PET! Visit this organization's web site to see any additional information available about this pet.May 23, 2026, 2:02 pm

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Coco

Mastiff

Female, 2 yrs

Suffolk, VA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Coco is a true sweetheart. All she wants is some snuggles and some play time. She is super treat motivated and is super eager to learn as many tricks as possible!

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Tanner

Mastiff/Hound (Unknown Type)

Male, 5 yrs 5 mos

Roanoke, VA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Not good with kids, Good with dogs,

Story

Tanner is a handsome boy! He loves to take walks and lean into you for pets. He is a great car rider and really doesn't care where you are headed - he just wants to go along. He gets along with other dogs, but doesn't actually need a canine companion. He is not all that playful. He would love to be doted on and receive all of your attention. He is a pretty low maintenance dog with a good attitude.The Adoption Fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea, Tick and Heartworm Treatment and Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. Tanner's adoption fee (if picked up locally in Crossville, Tennessee) is $225. If transport is needed, his adoption fee is $525 (out of state, East Coast, Great Lakes or New England regions).Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to Your Browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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Bones

Mastiff

Female, 4 yrs 1 mo

Roanoke, VA

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with dogs, Good with cats, House-trained,

Story

Bones is a big girl with an even bigger heart. Weighing in at around 100 pounds, she may not realize her size—once she trusts you, she’ll happily climb into your lap or wrap you up in a big hug, showering you with sweet chin kisses.She can be shy at first and takes a little time to warm up, but once she does, her affectionate and loyal nature truly shines. Bones is housebroken and well-mannered in the home. She does well around cats, often choosing to ignore them, but she would do best as the only dog so she can soak up all the love and attention she deserves.Loud noises and thunderstorms can be scary for her, so she’ll need a patient, understanding home where she feels safe and secure.Bones is being rehomed through no fault of her own after the passing of her owner. She’s ready to find a loving family who will give her the comfort, stability, and affection she craves Bones' adoption fee is $275.FOCCAS is a foster based, non-profit rescue in Crossville, TN. The adoption fee Includes Age-Appropriate Vaccinations (DA2PPV, Bordetella, Rabies), Deworming, Spay/Neuter, Microchip, Flea/Tick/Heartworm Prevention, and Sheltering. Adult Dogs are Heartworm Tested and Treated as Needed. FOCCAS does not DNA test or guarantee breed. If transport is needed, there are additional fees to cover department of agriculture requirements and transport, the additional fee adds $300 to the adoption fee (any location out of Tennessee, East Coast, Great Lakes or New England regions)Thank You for Your Interest in Adopting a Canine Companion from Foccas-tn.org!To Apply Please Copy and Paste to your browser:https://service.sheltermanager.com/asmservice?account=hb2428&method=online_form_html&formid=41LOCATED IN CROSSVILLE, CUMBERLAND COUNTY, TN. WE CAN TRANSPORT OUT OF STATE, Visit out website for a full list of adoptable pets… https://foccas-tn.org/

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Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 3 mos

Wyethville, VA

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family He is neutered, microchipped, had recent cherry eye repair and up to date on all vaccines and preventions. Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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Mastiff puppies and dogs in Virginia

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Adopt a Mastiff near you in Virginia

Below are our newest added Mastiffs available for adoption in Virginia. To see more adoptable Mastiffs in Virginia, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Virginia cities

Mastiff shelters & rescues in Virginia

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics