Mastiff Adoption in Ohio: Mastiff Puppies for Sale in Ohio

Adopt a Mastiff near you in Ohio

Below are our newest added Mastiffs available for adoption in Ohio. To see more adoptable Mastiffs in Ohio, use the search tool below to enter specific criteria!

Dexi

Mastiff

Female, Puppy

Germantown, OH

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs,

Story

Meet Our Sweet Brindle Girl, Dexi! This adorable 8-month-old brindle mastiff mix puppy with the cutest floppy ears is pure love wrapped in fur! She has the sweetest personality and is happiest when she’s surrounded by people or playing with other dogs. She absolutely loves everyone she meets and gets along wonderfully with other pups, making her a perfect addition to a home with furry siblings. When she’s not making new friends, you’ll find her happily playing with her toys, enjoying a good meal, or snuggling with her foster family. She’s currently living with her two dog foster siblings, and she loves them so much! They’ve helped show her how fun life can be, and she’s ready to bring that same joy to her very own forever family. All of our dogs are spayed or neutered, up to date on age appropriate vaccinations, microchipped and if over 6 months of age, heartworm tested and on heartworm preventative in their foster home. We require an approved application to meet any of our dogs. We do not have a shelter location and will not arrange a meeting without an approved application. We strive to make sure the bios provided for our dogs are complete and accurate; we do understand that mistakes happen, however, so if you absolutely cannot find the answer to your question in the dog's bio, you can contact us for more information. We require a home visit for each dog we adopt out, so we adopt within a 2 hour radius of Dayton, OH. If you are outside of this radius, we encourage you to contact your local rescue or shelter. March 16, 2026, 1:19 pm

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Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 1 mo

Cincinnati, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

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RUTABAGA

Mastiff

Male, 7 yrs

Akron, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Chuck

Mastiff/Shepherd (Unknown Type)

Male, 4 yrs

Columbia Station, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Meet Chuck! 🐾 Chuck is a big, handsome young white Mastiff/Shepherd mix with an even bigger heart. Chuck loves people, and will happily lean in for pets and attention whenever he can get them. He also loves to have his fur brushed. His sweet personality and affectionate nature make him a wonderful companion for someone looking for a devoted best friend. Chuck also has plenty of enthusiasm for the world around him. He enjoys walks, and is eager to explore. If you’ve got room in your home—and your heart—for a big, lovable dog, Chuck might be the perfect match. Come meet him and see just how special this gentle giant truly is! ❤️

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Cassian

Mastiff

Male, 3 yrs

Xenia, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

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Mr Woofer

Mastiff

Male, 4 yrs

Liberty Center, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, House-trained,

Story

Mr Woofers is a 4 to 5 yr old neutered male Mastiff mix. He weighs about 75 lbs. We pulled Woofers from our local animal shelter after he was picked up as a stray. He can be a little cautious when meeting new people but warms up quickly. You can convince him to do anything for a treat. He is lower energy and enjoys just hanging out with his family. He will go for a walk and does occasionally like a good romp in the yard. He has been kind and gentle . He appears to be house trained . He is great with other dogs and children. He hasn't been tested with cats. He is up to date on shots and wormed. He is already neutered. The adoption fee is $400.00. If interested in meeting this cutie, please email heritagefarms08@gmail.com or call the foster at 419-779-0862 . He is being fostered in Ottawa Lake , Michigan. When emailing please include information about you and your family including other pets.

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Below are our newest added Mastiffs available for adoption in Ohio. To see more adoptable Mastiffs in Ohio, use the search tool below to enter specific criteria!

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Mastiff puppies and dogs in Ohio

Jump to:

Adopt a Mastiff near you in Ohio

Below are our newest added Mastiffs available for adoption in Ohio. To see more adoptable Mastiffs in Ohio, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Ohio cities

Mastiff shelters & rescues in Ohio

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics