Mastiff Adoption in Ohio: Mastiff Puppies for Sale in Ohio

Adopt a Mastiff near you in Ohio

Below are our newest added Mastiffs available for adoption in Ohio. To see more adoptable Mastiffs in Ohio, use the search tool below to enter specific criteria!

Peanut

Mastiff/Labrador Retriever

Female, 1 yr

Valley View, OH

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

***We are not taking inquiries on Peanut at this time***

Learn More

Leo

Mastiff

Male, 3 yrs 7 mos

Athens, OH

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Story

At just 3.5 years old, Leo the Mastiff is a beautiful mix of strength and sweetness. While he may look big and rugged at first glance, his true personality is all heart. After spending much of his life outdoors, Leo has made it clear that he much prefers the comforts of indoor living. His favorite place is a cozy bed where he can relax and feel safe.Leo has a calm and gentle nature. He enjoys walking alongside other dogs and makes a wonderful companion on quiet strolls. At home, he would likely be happiest as the only dog, soaking up all the love and attention, while still enjoying occasional walks with canine friends.This sweet boy also loves car rides and is always happy to join you on an adventure. When it is time to settle in, Leo is all about cuddles and being close to his person.Leo is looking for a home where he can fully enjoy the indoor life he loves, with someone who appreciates a loyal and affectionate companion.If you are ready to welcome a big, loving dog into your life, Leo is ready to meet you!Submit an application at athenshumane.org/adopt

Learn More

ROSCOE

Mastiff

Male, 2 yrs

Akron, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Story

Learn More

Moose

Mastiff

Male, 4 yrs 6 mos

Brunswick, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

House-trained,

Story

Live alone? Need a ‘protector’ of sorts? Moose is the best man for the job! He would like to submit his application now. He’ll gladly take just room and board (he’s a food whore, will eat anything in your fridge) and lots of love for the job! Moose has a fierce loyalty to the people he loves. He is extremely affectionate and loving. He does not skim on kisses He loves laying next to his people, just chilling and being in the moment with them. Outside, he loves to play fetch. He’ll play fetch until the cows come home. This boy brings the ball back and patiently waits for it to be thrown again. He also chases birds and small animals so no cats for Moosey Goosey! Moose loves the outdoors. He’ll literally hang out outside all day if you let him. Moose is 4.5 years old, 75lb Mix breed. He is looking for an adult only home due to his initial distrust of people he does not know. Moose is terrified of the world. He is hoping his new family will be patient and show him how to trust. He yearns to be understood, gain confidence and freely love and trust. He is fiercely loyal and protective of the ones he loves but getting there is a journey. The end results is so rewarding, though. You will be so loved, and you will never feel scared or alone again. A fenced yard is a must.

Learn More

Dexi

Mastiff

Female, Puppy

Germantown, OH

Size

(when grown) Med. 26-60 lbs (12-27 kg)

Details

Good with kids, Good with dogs,

Story

Meet Our Sweet Brindle Girl, Dexi! This adorable 8-month-old brindle mastiff mix puppy with the cutest floppy ears is pure love wrapped in fur! She has the sweetest personality and is happiest when she’s surrounded by people or playing with other dogs. She absolutely loves everyone she meets and gets along wonderfully with other pups, making her a perfect addition to a home with furry siblings. When she’s not making new friends, you’ll find her happily playing with her toys, enjoying a good meal, or snuggling with her foster family. She’s currently living with her two dog foster siblings, and she loves them so much! They’ve helped show her how fun life can be, and she’s ready to bring that same joy to her very own forever family. All of our dogs are spayed or neutered, up to date on age appropriate vaccinations, microchipped and if over 6 months of age, heartworm tested and on heartworm preventative in their foster home. We require an approved application to meet any of our dogs. We do not have a shelter location and will not arrange a meeting without an approved application. We strive to make sure the bios provided for our dogs are complete and accurate; we do understand that mistakes happen, however, so if you absolutely cannot find the answer to your question in the dog's bio, you can contact us for more information. We require a home visit for each dog we adopt out, so we adopt within a 2 hour radius of Dayton, OH. If you are outside of this radius, we encourage you to contact your local rescue or shelter. March 17, 2026, 5:54 pm

Learn More

Ralph BW

Mastiff/Mixed Breed (Large)

Male, 1 yr 2 mos

Cincinnati, OH

Size

(when grown) Large 61-100 lbs (28-45 kg)

Details

Good with kids, Good with dogs, Good with cats,

Story

Ralph the Derp! Ralph is a huge friendly, enthusiastic, uncoordinated 4-legged energetic goofball! He was rescued from “death row” at a high kill shelter, as a skinny stray with a treatable skin condition. His fur has almost completely grown in & he is now at a healthy weight. This overgrown mastiff/Cane Corso mix pup has no comprehension of his size, leaning into humans for affection or trying to ooze onto laps for cuddles. He is being trained not to jump and not to paw for attention/affection/play because he currently has 85# of mass behind those “congenial” moves. Ralph plays well with dogs of all sizes, but would do best with med-to-larger dogs due to his size & poorly curbed gusto. He hordes toys, taking them all to his chosen dog bed of the day. He likes to carry a special toy “baby” in his mouth when going out in the yard. He does need to be fed in his crate & will guard his empty food bowl from other dogs, unless he is distracted with a toy & led outdoors after meals. He is great on a leash, makes awesome grunty sounds when cuddled, enjoys baths. Ralph will make a great addition to an active family with older children. He is eager to please, food and affection oriented (although a bit stubborn at times), making him an ideal candidate for success with continuation of his training. Please consider adopting the gorgeous big derp into your home. Attributes: In training to avoid jumping/pawing Active family He is neutered, microchipped, had recent cherry eye repair and up to date on all vaccines and preventions. Local adoption fee is $200(in TX) Out of state adoption fee is $450 (includes transport to your area)

Learn More

Use the search tool below to browse adoptable Mastiff puppies and adults Mastiff in Ohio.

Mastiff puppies and dogs in Ohio

Jump to:

Adopt a Mastiff near you in Ohio

Below are our newest added Mastiffs available for adoption in Ohio. To see more adoptable Mastiffs in Ohio, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Ohio cities

Mastiff shelters & rescues in Ohio

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics

Home

Adopt a Dog

Adopt a Mastiff

Ohio

Mastiff puppies and dogs in Ohio

Jump to:

Adopt a Mastiff near you in Ohio

Below are our newest added Mastiffs available for adoption in Ohio. To see more adoptable Mastiffs in Ohio, use the search tool below to enter specific criteria!

Search for a Mastiff puppy or dog

Mastiff puppies and dogs in Ohio cities

Mastiff shelters & rescues in Ohio

Looking for a specific shelter or rescue?

Want to learn more about adopting a Mastiff puppy or dog ?

Mastiff information

Mastiff basics