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Puppies and dogs in De Soto, Missouri

Looking for a puppy or dog in De Soto, Missouri? Adopt a Pet can help you find a new best friend near you.

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Adopt a dog in De Soto, Missouri

These adorable dogs are available for adoption in De Soto, Missouri. To learn more about each adoptable dog, click on the "i" icon for fast facts, or their photo or name for full details.
Photo of Otis

Otis

Bull Terrier

Male, Adult
De Soto, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Otis was found in an abandoned building in St. Louis by my boyfriend. He took him to see if he was chipped. After we found out he wasn’t chipped I post him on a local facebook group to see if anyone was looking for him. No one claimed him so we took him to the vet and got all of his shots. Also got him neutered after a while of having him. We have been trying to get him okay with our other animals but yet he goes after our cat and doesn’t back away at all. We have to keep them separated and it’s very hard. Otis is such a sweet boy. He LOVES food. Otis really needs a gentle person to thrive in his life. Otis is neutered, housebroken, crate trained, and is good with other dogs!!
Photo of Tater

Tater

Bull Terrier Bull Terrier

Male, Adult
De Soto, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with cats, Spayed or Neutered,
Story
Tater was found on my street and just jumped in my car so I feed him and left him stay at my house. I don’t know about his vet records. He seems like he has been through a lot in life. His tongue is scarred up. He loves snuggling with me though. He is very food motivated.
Photo of Mac

Mac

American Pit Bull Terrier American Bulldog

Male, Adult
De Soto, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Not good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Mack is seven years old and loves being outside! He really enjoys being around all ages of kids and lounging around the house. He has lots of love and snuggles to give! He is house broken and will come with a cage. He does not do well with cats at all. He loves walks at the park and does very well keeping up on a leash! I am moving with my two young children and we are unable to bring our sweet guy with us.
Photo of Loki

Loki

American Staffordshire Terrier

Male, Senior
De Soto, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with dogs, Not good with cats, Needs experienced adopter, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
This is Loki! He will be seven in February! I am so sad to have to rehome him, but I know he will go to someone who can provide a better and bigger space for him. We are moving and unfortunately, cannot take him with us. He is a goofy boy. He loves to sunbathe in the summer, loves any and all kinds of treats, long walks, and scratches behind his ears. He is not a fan of cats.
Photo of Benny

Benny

German Shepherd Dog

Male, Adult
Hillsboro, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Not good with cats, Needs experienced adopter, House-trained,
Story
Hi, I’m Benny! I’m a good boy with a lot of love to give, but I have a LOT of energy and I'm looking for a new home. 🐾❤️I am:• 70 lbs and purebred• House trained and microchipped• High energy and needing plenty of exercise• Loving, loyal, and full of potential• Best in a home without catsI’ve been having a hard time getting along with the cat in my current home, and I keep going after her. My family has tried to manage the situation, but they don’t feel comfortable putting her at risk. I need someone with the time, patience, and experience to work with me, help me learn boundaries, and give me the one-on-one attention I need to thrive. I'm just waiting for my person to give me that chance. 🐶❤️💰 Rehoming fee: $50 to ensure he is going to serious inquirers only.
Photo of Mack

Mack

Labrador Retriever

Male, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered,
Story
Hi, I’m Mack! I’m a little guy with a BIG sense of adventure! The minute my paws hit the great outdoors, I’m off to explore. If there’s fun happening, you can bet I want to be part of it! And those big dogs? I may be smaller, but that doesn’t stop me from trying to keep up! I’ll run alongside them, join in the fun, and prove that little puppies can have BIG adventures too! Want to know my favorite thing? Water! I love, love, LOVE water! Splashing and playing in the water is my idea of a perfect adventure. I’m also potty trained and crate trained, so I’ve already got some important skills under my belt! When the exploring and splashing are over, I’m ready for my other favorite things: giving lots of puppy kisses and cuddling up with my people. ❤️ Little guy with a big adventurous spirit Loves trying to keep up with the big dogs Loves, loves, LOVES water Generous with the puppy kisses ❤️ Loves to cuddle Potty trained and crate trained Ready to find my forever family If you’re looking for a sweet, adventurous little sidekick who’s always ready to play hard and cuddle harder, I might be your perfect match! Mack's adoption fee is $300.00 which includes 3 rounds of shots, neuter, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  September 18, 2026, 2:25 pm

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Dog shelters and rescues in De Soto, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for dogs in De Soto, Missouri. Browse these rescues and shelters below.

Here are a few organizations closest to you:

Rescue

Canines in Crisis, Inc.

De Soto, MO 63020

Pet Types: dogs

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Rescue

Rat Terrier ResQ - MO

Festus, MO 63028

Pet Types: dogs

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Shelter

Jefferson County Animal Control

4848 State Rt 30, House Springs, MO 63028

Pet Types: cats, dogs, rabbits, small animals

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Rescue

We Are Not Disposable

Festus, MO 63028

Pet Types: dogs

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Rescue

Paws for Consideration

2355 South Drive, Festus, MO 63028

Pet Types: cats, dogs

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Rescue

Advocates 4 Animals Pet Food Pantry

Hillsboro, MO 63050

Pet Types: dogs

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Shelter

Coalition for Animal Rescue and Education

Hillsboro, MO 63050

Pet Types: cats, dogs, horses

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Rescue

Flawdogs Adoptions

8646 highway ee / po box 99, morse mill, MO 63066

Pet Types: dogs

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Rescue

Recycling Rover

The Rainbow Ranch, BOX 209, Morse Mill, MO 63066

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

Harter's Hospice and Puppy Rescue

Pevely, MO 63070

Pet Types: dogs

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Looking for a specific shelter or rescue?

For a comprehensive list of all shelters and rescues, try our search page. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Looking for a specific breed?

Select from the options below to view adoptable puppies and dogs in De Soto, Missouri and nearby cities.

Popular dog breeds

Affenpinscher Afghan Hound Airedale Terrier Akbash Akita Alaskan Klee Kai Alaskan Malamute American Bulldog American Cocker Spaniel American Eskimo Dog American Hairless Terrier American Pit Bull Terrier American Staffordshire Terrier Anatolian Shepherd Aussiedoodle Australian Cattle Dog Australian Kelpie Australian Shepherd Australian Terrier Basenji Basset Hound Beagle Bearded Collie Beauceron Bedlington Terrier Belgian Laekenois Belgian Malinois Belgian Shepherd Belgian Tervuren Bernedoodle Bernese Mountain Dog Bichon Frise Black Mouth Cur Black and Tan Coonhound Bloodhound Blue Lacy/Texas Lacy Bluetick Coonhound Bolognese Border Collie Border Terrier Borzoi Boston Terrier Bouvier des Flandres Boxer Boykin Spaniel Briard Brittany Brussels Griffon Bull Terrier Bullmastiff Cairn Terrier Canaan Dog Cane Corso Cardigan Welsh Corgi Carolina Dog Catahoula Leopard Dog Caucasian Shepherd Dog Cavachon Cavalier King Charles Spaniel Cavapoo Chesapeake Bay Retriever Chihuahua Chinese Crested Chinook Chiweenie Chow Chow Clumber Spaniel Cockapoo Cocker Spaniel Collie Coonhound Corgi Coton de Tulear Curly-Coated Retriever Dachshund Dalmatian Dandie Dinmont Terrier Doberman Pinscher Dogo Argentino Dogue de Bordeaux Dutch Shepherd English (Redtick) Coonhound English Bulldog English Cocker Spaniel English Setter English Shepherd English Springer Spaniel English Toy Spaniel Entlebucher Feist Field Spaniel Fila Brasileiro Finnish Lapphund Finnish Spitz Flat-Coated Retriever Fox Terrier (Smooth) Fox Terrier (Toy) Fox Terrier (Wirehaired) Foxhound French Bulldog German Pinscher German Shepherd Dog German Shorthaired Pointer German Spitz German Wirehaired Pointer Glen of Imaal Terrier Goberian Golden Retriever Goldendoodle Gordon Setter Great Dane Great Pyrenees Greater Swiss Mountain Dog Greyhound Halden Hound (Haldenstrover) Harrier Havanese Horgi Hovawart Husky Ibizan Hound Icelandic Sheepdog Irish Setter Irish Terrier Irish Water Spaniel Irish Wolfhound Italian Greyhound Italian Spinone Jack Russell Terrier Japanese Chin Jindo Kai Dog Karelian Bear Dog Keeshond Kerry Blue Terrier Kishu Komondor Kuvasz Kyi Leo Labradoodle Labrador Retriever Lakeland Terrier Lancashire Heeler Leonberger Lhasa Apso Löwchen Maltese Maltipoo Manchester Terrier Maremma Sheepdog Mastiff Miniature Bull Terrier Miniature Dachshund Miniature Pinscher Morkie Mountain Cur Munsterlander Mutt Neapolitan Mastiff Newfoundland Norfolk Terrier Norwegian Buhund Norwegian Elkhound Norwegian Lundehund Norwich Terrier Nova Scotia Duck-Tolling Retriever Old English Sheepdog Olde English Bulldogge Otterhound Papillon Parson Russell Terrier Patterdale Terrier (Fell Terrier) Pekingese Pembroke Welsh Corgi Petit Basset Griffon Vendeen Pharaoh Hound Pitsky Plott Hound Podengo Portugueso Pointer Polish Lowland Sheepdog Pomeranian Pomsky Poodle (Miniature) Poodle (Standard) Poodle (Toy or Tea Cup) Portuguese Water Dog Presa Canario Pug Puggle Puli Pumi Rat Terrier Redbone Coonhound Rhodesian Ridgeback Rottweiler Saluki Samoyed Schiller Hound Schipperke Schnauzer (Giant) Schnauzer (Miniature) Schnauzer (Standard) Schnoodle Scottie, Scottish Terrier Scottish Deerhound Sealyham Terrier Shar Pei Sheepadoodle Sheltie, Shetland Sheepdog Sheppit Shepsky Shiba Inu Shih Poo Shih Tzu Silky Terrier Skye Terrier Sloughi St. Bernard Staffordshire Bull Terrier Sussex Spaniel Swedish Vallhund Texas Heeler Thai Ridgeback Tibetan Mastiff Tibetan Spaniel Tibetan Terrier Tosa Inu Treeing Walker Coonhound Vizsla Weimaraner Welsh Springer Spaniel Welsh Terrier Westie, West Highland White Terrier Wheaten Terrier Whippet Wirehaired Pointing Griffon Xoloitzcuintle/Mexican Hairless Yorkie Poo Yorkie, Yorkshire Terrier