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Puppies and dogs in De Soto, Missouri

Looking for a puppy or dog in De Soto, Missouri? Adopt a Pet can help you find a new best friend near you.

A pair of dogs

Adopt a dog in De Soto, Missouri

These adorable dogs are available for adoption in De Soto, Missouri. To learn more about each adoptable dog, click on the "i" icon for fast facts, or their photo or name for full details.
Photo of Cleo

Cleo

Pitsky Labrador Retriever

Female, Adult
Festus, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Needs experienced adopter, Spayed or Neutered,
Story
Cleo loves every body especially kids. Can get exited around new people.
Special Needs
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Photo of Baxter

Baxter

Boxer

Male, Young
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Needs special attention, Spayed or Neutered,
Story
Hi! My name is Baxter, and I'm an 8-week-old Boxer mix looking for my forever family! I'm having a great time in my foster home, where I'm learning all about crate training and working hard on my potty training. I'm a smart little guy and getting better every day. I love running and playing with the other dogs, exploring the backyard, and burning off all my puppy energy. After a day of fun, I'm more than happy to curl up for cuddles and soak up all the love. I'm looking for a family that will include me in their adventures.  Are you looking for a forever companion, are you the one?     Baxter’s adoption fee is $300.00 which includes 3 rounds of shots, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  July 16, 2026, 2:38 pm
Photo of Millie

Millie

Australian Shepherd

Female, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered,
Story
Meet Millie, the playful and smart puppy who loves making new friends. Every day, she wows everyone with her cleverness and boundless energy. Millie thrives on interaction and enjoys learning new games, always eager to please and quick to learn. She's the perfect companion for anyone looking for a friendly and intelligent dog. Adopting Millie means bringing home endless joy and a loyal friend who’s ready to be part of your family adventures. Millie's adoption fee is $350.00 which includes 3 rounds of shots, spay, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  July 16, 2026, 2:38 pm
Photo of Savanna

Savanna

Pit Bull Terrier

Female, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Savanna, a delightful puppy brimming with life and love. Her days are filled with playful antics and tender cuddles, making her the perfect companion for any fun-loving family. Savanna is not only good with other dogs, cats, and kids, but she's also making great strides in her crate and house training. Her curious nature keeps her eager to explore and learn new things, ensuring every day is an adventure. Savanna's sweet disposition and readiness to bond make her an ideal candidate for adoption. Bring Savanna home and let her fill your life with joy and playfulness! We believe she will be 30-40 pounds when full grown. Savanna's adoption fee is $300.00 which includes 3 rounds of shots, spay, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  July 16, 2026, 2:38 pm
Photo of Memphis

Memphis

Pit Bull Terrier

Male, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Memphis, a delightful puppy brimming with love and energy. This cuddly, playful, and curious little one is a joy to be around. Memphis is already making great strides in crate and house training, showing how smart he is! He gets along wonderfully with other dogs, cats, and children, making him the perfect addition to any family. With his sweet nature and eagerness to learn, Memphis is ready to bring happiness and companionship to a loving home. Consider making Memphis a part of your family and experience the joy he brings every day. We believe he will be 30-40 pounds when full grown. Memphis's  adoption fee is $300.00 which includes 3 rounds of shots, neuter, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  July 16, 2026, 2:38 pm
Photo of Tank

Tank

American Pit Bull Terrier

Male, Adult
Hillsboro, MO
Size
(when grown) Large 61-100 lbs (28-45 kg)
Details
Good with kids, Good with dogs, House-trained, Spayed or Neutered,
Story
Meet Tank — 93 pounds of pure heart, wrapped in a big, lovable body. At 4 years old, this handsome pitbull mix is the definition of a gentle giant. His favorite things? Ear scratches, belly rubs, and simply being near his people. Whether it’s playtime with other dogs or lounging beside a buddy who prefers naps, Tank fits right in. He’s easygoing, social, and knows how to match the energy around him. Grab a leash, and you’ll see his eyes light up — to Tank, it means adventure. Walks, car rides, time with you… it’s all his favorite. And when the day winds down, he’s perfectly content in his crate, finding comfort and security in his own cozy space. Tank is currently undergoing treatment for heartworms, and he’s taking it all in stride — because that’s who he is: resilient, trusting, and full of love to give. He’s looking for someone who sees past his size, understands his journey, and is ready to stand beside him as he gets his second chance. If you’re searching for a loyal companion… A steady presence through life’s ups and downs… A face that greets you with joy every single day… Tank is waiting for you. Tank’s adoption fee is $200.00 which includes all shots, neuter, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  July 16, 2026, 2:38 pm

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Use the search tool below to browse adoptable puppies and adult dogs in De Soto, Missouri.

Puppies and dogs in nearby cities

Dog shelters and rescues in De Soto, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for dogs in De Soto, Missouri. Browse these rescues and shelters below.

Here are a few organizations closest to you:

Rescue

Canines in Crisis, Inc.

De Soto, MO 63020

Pet Types: dogs

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Rescue

Rat Terrier ResQ - MO

Festus, MO 63028

Pet Types: dogs

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Shelter

Jefferson County Animal Control

4848 State Rt 30, House Springs, MO 63028

Pet Types: cats, dogs, rabbits, small animals

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Rescue

We Are Not Disposable

Festus, MO 63028

Pet Types: dogs

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Rescue

Paws for Consideration

2355 South Drive, Festus, MO 63028

Pet Types: cats, dogs

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Rescue

Advocates 4 Animals Pet Food Pantry

Hillsboro, MO 63050

Pet Types: dogs

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Shelter

Coalition for Animal Rescue and Education

Hillsboro, MO 63050

Pet Types: cats, dogs, horses

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Rescue

Flawdogs Adoptions

8646 highway ee / po box 99, morse mill, MO 63066

Pet Types: dogs

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Rescue

Recycling Rover

The Rainbow Ranch, BOX 209, Morse Mill, MO 63066

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

Harter's Hospice and Puppy Rescue

Pevely, MO 63070

Pet Types: dogs

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Looking for a specific shelter or rescue?

For a comprehensive list of all shelters and rescues, try our search page. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Looking for a specific breed?

Select from the options below to view adoptable puppies and dogs in De Soto, Missouri and nearby cities.

Popular dog breeds

Affenpinscher Afghan Hound Airedale Terrier Akbash Akita Alaskan Klee Kai Alaskan Malamute American Bulldog American Cocker Spaniel American Eskimo Dog American Hairless Terrier American Pit Bull Terrier American Staffordshire Terrier Anatolian Shepherd Aussiedoodle Australian Cattle Dog Australian Kelpie Australian Shepherd Australian Terrier Basenji Basset Hound Beagle Bearded Collie Beauceron Bedlington Terrier Belgian Laekenois Belgian Malinois Belgian Shepherd Belgian Tervuren Bernedoodle Bernese Mountain Dog Bichon Frise Black Mouth Cur Black and Tan Coonhound Bloodhound Blue Lacy/Texas Lacy Bluetick Coonhound Bolognese Border Collie Border Terrier Borzoi Boston Terrier Bouvier des Flandres Boxer Boykin Spaniel Briard Brittany Brussels Griffon Bull Terrier Bullmastiff Cairn Terrier Canaan Dog Cane Corso Cardigan Welsh Corgi Carolina Dog Catahoula Leopard Dog Caucasian Shepherd Dog Cavachon Cavalier King Charles Spaniel Cavapoo Chesapeake Bay Retriever Chihuahua Chinese Crested Chinook Chiweenie Chow Chow Clumber Spaniel Cockapoo Cocker Spaniel Collie Coonhound Corgi Coton de Tulear Curly-Coated Retriever Dachshund Dalmatian Dandie Dinmont Terrier Doberman Pinscher Dogo Argentino Dogue de Bordeaux Dutch Shepherd English (Redtick) Coonhound English Bulldog English Cocker Spaniel English Setter English Shepherd English Springer Spaniel English Toy Spaniel Entlebucher Feist Field Spaniel Fila Brasileiro Finnish Lapphund Finnish Spitz Flat-Coated Retriever Fox Terrier (Smooth) Fox Terrier (Toy) Fox Terrier (Wirehaired) Foxhound French Bulldog German Pinscher German Shepherd Dog German Shorthaired Pointer German Spitz German Wirehaired Pointer Glen of Imaal Terrier Goberian Golden Retriever Goldendoodle Gordon Setter Great Dane Great Pyrenees Greater Swiss Mountain Dog Greyhound Halden Hound (Haldenstrover) Harrier Havanese Horgi Hovawart Husky Ibizan Hound Icelandic Sheepdog Irish Setter Irish Terrier Irish Water Spaniel Irish Wolfhound Italian Greyhound Italian Spinone Jack Russell Terrier Japanese Chin Jindo Kai Dog Karelian Bear Dog Keeshond Kerry Blue Terrier Kishu Komondor Kuvasz Kyi Leo Labradoodle Labrador Retriever Lakeland Terrier Lancashire Heeler Leonberger Lhasa Apso Löwchen Maltese Maltipoo Manchester Terrier Maremma Sheepdog Mastiff Miniature Bull Terrier Miniature Dachshund Miniature Pinscher Morkie Mountain Cur Munsterlander Mutt Neapolitan Mastiff Newfoundland Norfolk Terrier Norwegian Buhund Norwegian Elkhound Norwegian Lundehund Norwich Terrier Nova Scotia Duck-Tolling Retriever Old English Sheepdog Olde English Bulldogge Otterhound Papillon Parson Russell Terrier Patterdale Terrier (Fell Terrier) Pekingese Pembroke Welsh Corgi Petit Basset Griffon Vendeen Pharaoh Hound Pitsky Plott Hound Podengo Portugueso Pointer Polish Lowland Sheepdog Pomeranian Pomsky Poodle (Miniature) Poodle (Standard) Poodle (Toy or Tea Cup) Portuguese Water Dog Presa Canario Pug Puggle Puli Pumi Rat Terrier Redbone Coonhound Rhodesian Ridgeback Rottweiler Saluki Samoyed Schiller Hound Schipperke Schnauzer (Giant) Schnauzer (Miniature) Schnauzer (Standard) Schnoodle Scottie, Scottish Terrier Scottish Deerhound Sealyham Terrier Shar Pei Sheepadoodle Sheltie, Shetland Sheepdog Sheppit Shepsky Shiba Inu Shih Poo Shih Tzu Silky Terrier Skye Terrier Sloughi St. Bernard Staffordshire Bull Terrier Sussex Spaniel Swedish Vallhund Texas Heeler Thai Ridgeback Tibetan Mastiff Tibetan Spaniel Tibetan Terrier Tosa Inu Treeing Walker Coonhound Vizsla Weimaraner Welsh Springer Spaniel Welsh Terrier Westie, West Highland White Terrier Wheaten Terrier Whippet Wirehaired Pointing Griffon Xoloitzcuintle/Mexican Hairless Yorkie Poo Yorkie, Yorkshire Terrier