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Puppies and dogs in De Soto, Missouri

Looking for a puppy or dog in De Soto, Missouri? Adopt a Pet can help you find a new best friend near you.

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Adopt a dog in De Soto, Missouri

These adorable dogs are available for adoption in De Soto, Missouri. To learn more about each adoptable dog, click on the "i" icon for fast facts, or their photo or name for full details.
We'll also keep you updated on Oakley's adoption status with email updates.
Photo of Oakley

Oakley

Black Mouth Cur

Female, Adult
Desoto, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Not good with cats, House-trained, Shots are up-to-date,
Story
Oakley is her name. She is the sweetest. She does her own thing. Has lots of energy but loves to lay with you.
We'll also keep you updated on Bailey's adoption status with email updates.
Photo of Bailey

Bailey

Mutt

Female, Adult
De Soto, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Not good with cats, House-trained, Spayed or Neutered,
Story
Bailey is a great family dog. She is very playful. She does not do well with cats or chickens. She could probably be trained not chase them. We took her in from a bad situation. It was only supposed to be temporary. They cannot take her back. We have an aggressive dog that does not like other dogs. Bailey is about 3 years old. Very good temperament. We are running on single income and cannot afford shots at this time. She has been kept up to date until this year.
We'll also keep you updated on Draco's adoption status with email updates.
Photo of Draco

Draco

American Pit Bull Terrier

Male, Young
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, House-trained, Spayed or Neutered, Shots are up-to-date,
Story
Got him from the humane society when he was about 10 months old. He will be 2 in October. Draco is a good boy that loves playing fetch and will drop the ball right at your feet. He is e-collar trained. We live on 6 acres, no fenced yard but he stays close. He has been exposed to chickens, horses, pigs, other dogs, cats and children. He is a hyper puppy that wants attention and love. He will run and play outside for as long as you let him and will come inside and plop and be lazy. Best home to go to would be someone with a fenced in yard with a doggy door or time to let him out often as he does have accidents inside.
We'll also keep you updated on Skeeter's adoption status with email updates.
Photo of Skeeter

Skeeter

Terrier (Unknown Type, Medium)

Male, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Good with cats, Spayed or Neutered,
Story
Meet Skeeter, a delightful puppy who's always ready for a game or a snuggle! His days are filled with playful zoomies and cozy cuddle sessions. Skeeter loves everyone he meets, be they dogs or cats, and his cheerful demeanor lights up the room. He's the perfect companion for anyone looking for a loving and lively friend. Bringing Skeeter into your home means endless fun and affection. He's just waiting for someone to share all his love and playful adventures with. Adopt Skeeter today and fill your life with joy! Skeeter's adoption fee is $300.00 which includes 3 rounds of shots, neuter, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  March 29, 2026, 11:00 pm
We'll also keep you updated on Frankie's adoption status with email updates.
Photo of Frankie

Frankie

Pit Bull Terrier American Pit Bull Terrier

Female, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered,
Story
Frankie is a 4-month-old Pitbull mix with a beautiful chocolate brown coat and charming white markings. She may be small now, but her personality is anything but—this sweet girl is full of life, love, and playful energy! Frankie is incredibly social and would thrive in a home with kids or another playful dog. She absolutely loves making new friends, whether they have two legs or four, and she’s always up for a game or a cuddle session afterward. Car rides? She’s all in! Frankie doing wonderfully with both potty training and crate training. She’s also learning her basic commands and walking nicely on a leash with a harness.   Why you’ll love Frankie:     •    Friendly, affectionate, and playful     •    Great with kids and other dogs     •    Loves both playtime and snuggles     •    Smart and eager to learn   Her ideal home: Frankie would do best in a home that can continue her training, provide lots of playtime, and give her the love and attention every puppy deserves. She would especially enjoy having a canine companion or an active family to grow up with. Frankie is ready to find her forever family and fill their home with joy, laughter, and puppy kisses. Frankie's adoption fee is $300.00 which includes 3 rounds of shots, spay, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  March 29, 2026, 11:00 pm
We'll also keep you updated on Posey's adoption status with email updates.
Photo of Posey

Posey

Terrier (Unknown Type, Medium) American Pit Bull Terrier

Female, Puppy
Hillsboro, MO
Size
(when grown) Med. 26-60 lbs (12-27 kg)
Details
Good with kids, Good with dogs, Spayed or Neutered,
Story
Meet Posey, a delightful puppy brimming with playfulness and affection. Her days are filled with joy as she frolics around, making friends with everyone she meets. Posey has a special knack for brightening up the room with her sweet, cuddly nature. She loves playing with toys and enjoys the company of other animals, always eager to engage in a fun game or a gentle snuggle session. Adopting Posey means bringing home a bundle of love and joy, ready to fill your life with endless playful moments and affection. Posey's adoption fee is $300.00 which includes 3 rounds of shots, spay, microchip and 1 month of heartworm preventative. If you are interested, please complete the Adoption Application on our website at a4apetpantry.org Disclaimer: Visual breed identification in dogs is unreliable, so for most of our dogs, we are only guessing at breed mix.  March 14, 2026, 2:52 pm

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Use the search tool below to browse adoptable puppies and adult dogs in De Soto, Missouri.

Puppies and dogs in nearby cities

Dog shelters and rescues in De Soto, Missouri

There are animal shelters and rescues that focus specifically on finding great homes for dogs in De Soto, Missouri. Browse these rescues and shelters below.

Here are a few organizations closest to you:

Rescue

Canines in Crisis, Inc.

De Soto, MO 63020

Pet Types: dogs

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Shelter

Jefferson County Animal Control

4848 State Rt 30, House Springs, MO 63028

Pet Types: cats, dogs, rabbits, small animals

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Rescue

Rat Terrier ResQ - MO

Festus, MO 63028

Pet Types: dogs

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Rescue

Paws for Consideration

2355 South Drive, Festus, MO 63028

Pet Types: cats, dogs

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Rescue

We Are Not Disposable

Festus, MO 63028

Pet Types: dogs

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Rescue

Advocates 4 Animals Pet Food Pantry

Hillsboro, MO 63050

Pet Types: dogs

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Shelter

Coalition for Animal Rescue and Education

Hillsboro, MO 63050

Pet Types: cats, dogs, horses

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Rescue

Recycling Rover

The Rainbow Ranch, BOX 209, Morse Mill, MO 63066

Pet Types: cats, birds, dogs, farm animals, horses, rabbits, reptiles, small animals

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Rescue

Flawdogs Adoptions

8646 highway ee / po box 99, morse mill, MO 63066

Pet Types: dogs

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Rescue

Harter's Hospice and Puppy Rescue

Pevely, MO 63070

Pet Types: dogs

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Looking for a specific shelter or rescue?

For a comprehensive list of all shelters and rescues, try our search page. We have more than 17,000 organizations in our database with furry pals waiting for a new home!

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Looking for a specific breed?

Select from the options below to view adoptable puppies and dogs in De Soto, Missouri and nearby cities.

Popular dog breeds

Affenpinscher Afghan Hound Airedale Terrier Akbash Akita Alaskan Klee Kai Alaskan Malamute American Bulldog American Cocker Spaniel American Eskimo Dog American Hairless Terrier American Pit Bull Terrier American Staffordshire Terrier Anatolian Shepherd Aussiedoodle Australian Cattle Dog Australian Kelpie Australian Shepherd Australian Terrier Basenji Basset Hound Beagle Bearded Collie Beauceron Bedlington Terrier Belgian Laekenois Belgian Malinois Belgian Shepherd Belgian Tervuren Bernedoodle Bernese Mountain Dog Bichon Frise Black Mouth Cur Black and Tan Coonhound Bloodhound Blue Lacy/Texas Lacy Bluetick Coonhound Bolognese Border Collie Border Terrier Borzoi Boston Terrier Bouvier des Flandres Boxer Boykin Spaniel Briard Brittany Brussels Griffon Bull Terrier Bullmastiff Cairn Terrier Canaan Dog Cane Corso Cardigan Welsh Corgi Carolina Dog Catahoula Leopard Dog Caucasian Shepherd Dog Cavachon Cavalier King Charles Spaniel Cavapoo Chesapeake Bay Retriever Chihuahua Chinese Crested Chinook Chiweenie Chow Chow Clumber Spaniel Cockapoo Cocker Spaniel Collie Coonhound Corgi Coton de Tulear Curly-Coated Retriever Dachshund Dalmatian Dandie Dinmont Terrier Doberman Pinscher Dogo Argentino Dogue de Bordeaux Dutch Shepherd English (Redtick) Coonhound English Bulldog English Cocker Spaniel English Setter English Shepherd English Springer Spaniel English Toy Spaniel Entlebucher Feist Field Spaniel Fila Brasileiro Finnish Lapphund Finnish Spitz Flat-Coated Retriever Fox Terrier (Smooth) Fox Terrier (Toy) Fox Terrier (Wirehaired) Foxhound French Bulldog German Pinscher German Shepherd Dog German Shorthaired Pointer German Spitz German Wirehaired Pointer Glen of Imaal Terrier Goberian Golden Retriever Goldendoodle Gordon Setter Great Dane Great Pyrenees Greater Swiss Mountain Dog Greyhound Halden Hound (Haldenstrover) Harrier Havanese Horgi Hovawart Husky Ibizan Hound Icelandic Sheepdog Irish Setter Irish Terrier Irish Water Spaniel Irish Wolfhound Italian Greyhound Italian Spinone Jack Russell Terrier Japanese Chin Jindo Kai Dog Karelian Bear Dog Keeshond Kerry Blue Terrier Kishu Komondor Kuvasz Kyi Leo Labradoodle Labrador Retriever Lakeland Terrier Lancashire Heeler Leonberger Lhasa Apso Löwchen Maltese Maltipoo Manchester Terrier Maremma Sheepdog Mastiff Miniature Bull Terrier Miniature Dachshund Miniature Pinscher Morkie Mountain Cur Munsterlander Mutt Neapolitan Mastiff Newfoundland Norfolk Terrier Norwegian Buhund Norwegian Elkhound Norwegian Lundehund Norwich Terrier Nova Scotia Duck-Tolling Retriever Old English Sheepdog Olde English Bulldogge Otterhound Papillon Parson Russell Terrier Patterdale Terrier (Fell Terrier) Pekingese Pembroke Welsh Corgi Petit Basset Griffon Vendeen Pharaoh Hound Pitsky Plott Hound Podengo Portugueso Pointer Polish Lowland Sheepdog Pomeranian Pomsky Poodle (Miniature) Poodle (Standard) Poodle (Toy or Tea Cup) Portuguese Water Dog Presa Canario Pug Puggle Puli Pumi Rat Terrier Redbone Coonhound Rhodesian Ridgeback Rottweiler Saluki Samoyed Schiller Hound Schipperke Schnauzer (Giant) Schnauzer (Miniature) Schnauzer (Standard) Schnoodle Scottie, Scottish Terrier Scottish Deerhound Sealyham Terrier Shar Pei Sheepadoodle Sheltie, Shetland Sheepdog Sheppit Shepsky Shiba Inu Shih Poo Shih Tzu Silky Terrier Skye Terrier Sloughi St. Bernard Staffordshire Bull Terrier Sussex Spaniel Swedish Vallhund Texas Heeler Thai Ridgeback Tibetan Mastiff Tibetan Spaniel Tibetan Terrier Tosa Inu Treeing Walker Coonhound Vizsla Weimaraner Welsh Springer Spaniel Welsh Terrier Westie, West Highland White Terrier Wheaten Terrier Whippet Wirehaired Pointing Griffon Xoloitzcuintle/Mexican Hairless Yorkie Poo Yorkie, Yorkshire Terrier